{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:12:34Z","timestamp":1773659554407,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,1,27]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Fibroblast growth factor\u201323 (\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023) is a phosphaturic factor previously associated with left ventricular hypertrophy and systolic dysfunction among individuals with chronic kidney disease. Whether\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023 acts directly to induce left ventricular hypertrophy, potentially independent of its klotho coreceptor, remains uncertain. We investigated associations of\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023 with cardiac structural abnormalities among individuals with a broad range of kidney function and explored potential biological mechanisms using cardiac magnetic resonance imaging and histology in\n              <jats:italic>klotho<\/jats:italic>\n              \u2010null mice, an established model of constitutively elevated\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among 887 participants with coronary artery disease in the\n              <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n              eart and\n              <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n              oul\n              <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n              tudy,\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023 was modestly associated with worse left ventricular ejection fraction (\u22121.0% per standard deviation increase in ln\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023; standard error, 0.4%), but was not associated with the overall prevalence of concentric hypertrophy (odds ratio, 1.5;\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.9 to 2.4) or eccentric hypertrophy (odds ratio, 1.1;\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.9 to 1.3).\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023 was only associated with concentric hypertrophy among individuals with diminished kidney function (\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              &lt;60\u00a0mL\/min per 1.73\u00a0m\n              <jats:sup>2<\/jats:sup>\n              ; odds ratio, 2.3;\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.0 to 5.3;\n              <jats:italic>P<\/jats:italic>\n              \u2010interaction=0.28). Comparing\n              <jats:italic>klotho<\/jats:italic>\n              \u2010null with wild\u2010type mice, null mice did not have greater left ventricular mass (\n              <jats:italic>P<\/jats:italic>\n              =0.37) or a lower ejection fraction (\n              <jats:italic>P<\/jats:italic>\n              =0.94).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Together, our results suggest that\n              <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n              \u201023 is unlikely to have major effects on cardiovascular structure and function among patients free of substantial chronic kidney disease, and these effects may not be independent of the klotho coreceptor.\n            <\/jats:p>\n          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