{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:20:10Z","timestamp":1790734810267,"version":"4.1.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,1,27]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Inflammation is fundamental to the development of atherosclerosis. We examined the effect of anti\u2010inflammatory doses of salicylate on endothelium\u2010dependent vasodilation, a biomarker of cardiovascular risk, in a broad range of subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a randomized, double\u2010blind, placebo\u2010controlled crossover trial evaluating the effects of 4\u00a0weeks of high\u2010dose salsalate (disalicylate) therapy on endothelium\u2010dependent flow\u2010mediated and endothelium\u2010independent vasodilation. Fifty\u2010eight subjects, including 17 with metabolic syndrome, 13 with atherosclerosis, and 28 healthy controls, were studied. Among all subjects,\n              <jats:styled-content style=\"fixed-case\">endothelium\u2010dependent flow\u2010mediated vasodilation<\/jats:styled-content>\n              decreased after salsalate compared with placebo therapy (\n              <jats:italic>P<\/jats:italic>\n              =0.01), whereas nitroglycerin\u2010mediated, endothelium\u2010independent vasodilation was unchanged (\n              <jats:italic>P<\/jats:italic>\n              =0.97).\n              <jats:styled-content style=\"fixed-case\">Endothelium\u2010dependent flow\u2010mediated vasodilation<\/jats:styled-content>\n              after salsalate therapy was impaired compared with placebo therapy in subjects with therapeutic salicylate levels (n=31,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.02) but not in subjects with subtherapeutic levels (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.2).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Salsalate therapy, particularly when therapeutic salicylate levels are achieved, impairs endothelium\u2010dependent vasodilation in a broad range of subjects. These data raise concern about the possible deleterious effects of anti\u2010inflammatory doses of salsalate on cardiovascular risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique Identifiers: NCT00760019 and NCT00762827.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.113.000609","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T03:16:35Z","timestamp":1388805395000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["The Effect of Salsalate Therapy on Endothelial Function in a Broad Range of Subjects"],"prefix":"10.1161","volume":"3","author":[{"given":"Anju","family":"Nohria","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine, Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Kinlay","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"},{"name":"Cardiovascular Division, VA Boston Healthcare System, West Roxbury, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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