{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:40:21Z","timestamp":1792658421665,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,1,27]]},"abstract":"\n Background<\/jats:title>\n \n Electrocardiography has been considered an important tool in the management of Chagas disease (ChD) patients, although its value in elderly infected patients is unknown. This study was designed to investigate the prevalence and prognostic value of electrocardiographic abnormalities in\n \n T<\/jats:styled-content>\n rypanosoma cruzi\n <\/jats:italic>\n infected and noninfected older adults.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We studied 1462 participants in Bambu\u00ed City,\n B<\/jats:styled-content>\n razil, with electrocardiogram (\n ECG<\/jats:styled-content>\n ) records classified by the\n M<\/jats:styled-content>\n innesota Code. Follow\u2010up time was 10\u00a0years; the endpoint was mortality. Adjustment for potential confounding variables included age, gender, conventional risk factors, and B\u2010type natriuretic peptide (\n BNP<\/jats:styled-content>\n ). The mean age was 69\u00a0years (60.9% women). The prevalence of ChD was 38.1% (n=557).\n ECG<\/jats:styled-content>\n abnormalities were more frequent in ChD patients (87.6% versus 77.7%,\n P<\/jats:italic>\n <0.001). Right bundle branch block (\n RBBB<\/jats:styled-content>\n ) with left anterior hemiblock (\n LAH<\/jats:styled-content>\n ) was strongly related to ChD (\n OR<\/jats:styled-content>\n : 11.99 [5.60 to 25.69]). During the mean follow\u2010up time of 8.7\u00a0years, 556 participants died (253 with ChD), and only 89 were lost to follow\u2010up.\n ECG<\/jats:styled-content>\n variables of independent prognostic value for death in ChD included absence of sinus rhythm, frequent ventricular and supraventricular premature beats, atrial fibrillation,\n RBBB<\/jats:styled-content>\n , old and possible old myocardial infarction, and left ventricular hypertrophy. The presence of any major\n ECG<\/jats:styled-content>\n abnormalities doubled the risk of death in ChD patients (\n HR<\/jats:styled-content>\n : 2.18 [1.35 to 3.53]), but it also increased the risk in non\u2010ChD subjects (\n HR<\/jats:styled-content>\n : 1.50 [1.07 to 2.10]); the risk of death increased with the number of major abnormalities in the same patient.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n ECG<\/jats:styled-content>\n abnormalities are more common among elderly Chagas disease patients and strongly predict adverse outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.113.000632","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T05:44:09Z","timestamp":1391838249000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":78,"title":["Electrocardiographic Abnormalities in Elderly Chagas Disease Patients: 10\u2010Year Follow\u2010Up of the Bambu\u00ed Cohort Study of Aging"],"prefix":"10.1161","volume":"3","author":[{"given":"Antonio Luiz P.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Brazil"},{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena S.","family":"Marcolino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Brazil"},{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Prineas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Prevention, Wake Forest University School of Medicine, Medical Center Boulevard, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Lima\u2010Costa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Medical School, Universidade Federal de Minas Gerais, Brazil"},{"name":"Department of Epidemiology & Prevention, Wake Forest University School of Medicine, Medical Center Boulevard, Winston\u2010Salem, NC"},{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.109"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.11.008"},{"key":"e_1_3_4_4_2","first-page":"1","volume-title":"First WHO Report on Neglected Tropical Diseases: Working to Overcome the Global Impact of Neglected Tropical Diseases","author":"World Health Organization","year":"2010","unstructured":"World Health Organization . 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