{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:21:25Z","timestamp":1791426085625,"version":"4.3.3"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,3,24]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cannabis is known to be associated with neuropsychiatric problems, but less is known about complications affecting other specified body systems. We report and analyze 35 recent remarkable cardiovascular complications following cannabis use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In\n                      <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                      rance, serious cases of abuse and dependence in response to the use of psychoactive substances must be reported to the national system of the\n                      <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                      rench Addictovigilance Network. We identified all spontaneous reports of cardiovascular complications related to cannabis use collected by the\n                      <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                      rench Addictovigilance Network from 2006 to 2010. We described the clinical characteristics of these cases and their evolution: 1.8% of all cannabis\u2010related reports (35\/1979) were cardiovascular complications, with patients being mostly men (85.7%) and of an average age of 34.3\u00a0years. There were 22 cardiac complications (20 acute coronary syndromes), 10 peripheral complications (lower limb or juvenile arteriopathies and Buerger\u2010like diseases), and 3 cerebral complications (acute cerebral angiopathy, transient cortical blindness, and spasm of cerebral artery). In 9 cases, the event led to patient death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Increased reporting of cardiovascular complications related to cannabis and their extreme seriousness (with a death rate of 25.6%) indicate cannabis as a possible risk factor for cardiovascular disease in young adults, in line with previous findings. Given that cannabis is perceived to be harmless by the general public and that legalization of its use is debated, data concerning its danger must be widely disseminated. Practitioners should be aware that cannabis may be a potential triggering factor for cardiovascular complications in young people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.113.000638","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T05:37:00Z","timestamp":1398317820000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":214,"title":["Cannabis Use: Signal of Increasing Risk of Serious Cardiovascular Disorders"],"prefix":"10.1161","volume":"3","author":[{"given":"Emilie","family":"Jouanjus","sequence":"first","affiliation":[{"name":"Centres d'\u00e9valuation et d'information sur la Pharmacod\u00e9pendance \u2013 Addictovigilance, Service de Pharmacologie M\u00e9dicale et Clinique, Centre Hospitalier Universitaire, Facult\u00e9 de M\u00e9decine, Toulouse, France"},{"name":"Inserm UMR1027, Toulouse, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"Centres d'\u00e9valuation et d'information sur la Pharmacod\u00e9pendance \u2013 Addictovigilance, Service de Pharmacologie M\u00e9dicale et Clinique, Centre Hospitalier Universitaire, Facult\u00e9 de M\u00e9decine, Toulouse, France"},{"name":"Inserm UMR1027, Toulouse, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Micallef","sequence":"additional","affiliation":[{"name":"Inserm UMR1027, Toulouse, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, France"},{"name":"Centres d'\u00c9valuation et d'Information sur la Pharmacod\u00e9pendance \u2013 Addictovigilance, Centre Hospitalier Universitaire, Service de Pharmacologie Clinique, Institut de Neurosciences Timone, Aix Marseille Universit\u00e9, Marseille Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The French Association of the Regional Abuse and Dependence Monitoring Centres (CEIP\u2010A) Working Group on Cannabis Complications*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38985.646481.55"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182949a2e"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00114-3"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1999.0493"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws461"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-362"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62296-9"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.4.495"},{"key":"e_1_3_5_11_2","first-page":"112","volume-title":"World Drug Report 2012","author":"UNODC","year":"2012","unstructured":"UNODC . 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