{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:05:32Z","timestamp":1785708332320,"version":"3.56.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,1,27]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Women are more likely than men to develop resistant hypertension, which is associated with excess risk of major adverse outcomes; however, the impact of resistant hypertension in women with ischemia has not been explicitly studied. In this Women's Ischemia Syndrome Evaluation (\n              <jats:styled-content style=\"fixed-case\">WISE<\/jats:styled-content>\n              ) analysis, we assessed long\u2010term adverse outcomes associated with apparent treatment\u2010resistant hypertension (\n              <jats:styled-content style=\"fixed-case\">aTRH<\/jats:styled-content>\n              ) among women with suspected myocardial ischemia referred for coronary angiography.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Women (n=927) were grouped according to baseline blood pressure (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              ): normotensive (no hypertension history,\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              &lt;140\/90\u00a0mm\u00a0Hg, no antihypertensive drugs); controlled (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              &lt;140\/90\u00a0mm\u00a0Hg and a hypertension diagnosis or on 1 to 3 drugs); uncontrolled (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              \u2265140\/90\u00a0mm\u00a0Hg on \u22642 drugs); or\n              <jats:styled-content style=\"fixed-case\">aTRH<\/jats:styled-content>\n              (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              \u2265140\/90\u00a0mm\u00a0Hg on 3 drugs or anyone on \u22654 drugs). Adverse outcomes (first occurrence of death [any cause], nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure or angina) were collected over 10\u00a0years of follow\u2010up. Apparent treatment\u2010resistant hypertension prevalence was 10.4% among those with hypertension. Women with\n              <jats:styled-content style=\"fixed-case\">aTRH<\/jats:styled-content>\n              had a greater incidence of adverse outcomes, compared with normotensive women (adjusted hazard ratio [\n              <jats:styled-content style=\"fixed-case\">HR],<\/jats:styled-content>\n              3.25; 95% confidence interval [\n              <jats:styled-content style=\"fixed-case\">CI],<\/jats:styled-content>\n              1.94 to 5.43), and women with controlled (\n              <jats:styled-content style=\"fixed-case\">HR,<\/jats:styled-content>\n              1.77; 95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              1.26 to 2.49) and uncontrolled (\n              <jats:styled-content style=\"fixed-case\">HR,<\/jats:styled-content>\n              1.62; 95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              1.15 to 2.27) hypertension; outcome differences were evident early in follow\u2010up. Risk of all\u2010cause death was greater in the\n              <jats:styled-content style=\"fixed-case\">aTRH<\/jats:styled-content>\n              group, compared to the normotensive women and women with controlled and uncontrolled hypertension.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this cohort of women with evidence of ischemia,\n              <jats:styled-content style=\"fixed-case\">aTRH<\/jats:styled-content>\n              was associated with a profoundly increased long\u2010term risk of major adverse events, including death, that emerged early during follow\u2010up.\n            <\/jats:p>\n          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PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Noel Bairey Merz","sequence":"additional","affiliation":[{"name":"Barbara Streisand Women's Heart Center, Cedars\u2010Sinai Heart Institute, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda M.","family":"Cooper\u2010DeHoff","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy &amp; Translational Research, College of Pharmacy, University of Florida, Gainesville, FL"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, 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