{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:40:36Z","timestamp":1792035636808,"version":"4.4.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,3,24]]},"abstract":"\n Background<\/jats:title>\n \n Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (\n BMI<\/jats:styled-content>\n ) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Women giving birth during the years 2004\u20132009, with no history of cardiovascular disease, renal insufficiency, pregnancy\u2010associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (\n BMI<\/jats:styled-content>\n <18.5\u00a0kg\/m\n 2<\/jats:sup>\n ), normal weight (\n BMI<\/jats:styled-content>\n =18.5 to <25\u00a0kg\/m\n 2<\/jats:sup>\n ), overweight (\n BMI<\/jats:styled-content>\n =25 to <30\u00a0kg\/m\n 2<\/jats:sup>\n ), obese\u2010I (\n BMI<\/jats:styled-content>\n =30 to <35\u00a0kg\/m\n 2<\/jats:sup>\n ), obese\u2010\n II<\/jats:styled-content>\n (\n BMI<\/jats:styled-content>\n =35 to <40\u00a0kg\/m\n 2<\/jats:sup>\n ), and obese\u2010\n III<\/jats:styled-content>\n (\n BMI<\/jats:styled-content>\n \u226540\u00a0kg\/m\n 2<\/jats:sup>\n ). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252\u00a0472 women with a median age of 30.4\u00a0years (\n IQR<\/jats:styled-content>\n =27.2;33.7) and a median follow\u2010up of 5.5\u00a0years (\n IQR<\/jats:styled-content>\n =3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (\n RR<\/jats:styled-content>\n s) of diabetes were: 0.84 (95% confidence interval [\n CI<\/jats:styled-content>\n ]=0.62 to 1.14) for underweight, 2.63 (\n CI<\/jats:styled-content>\n =2.36 to 2.93) for overweight, 4.83 (\n CI<\/jats:styled-content>\n =4.27 to 5.47) for obese grade\u2010I, 7.17 (\n CI<\/jats:styled-content>\n =6.10 to 8.48) for obese grade\u2010II, and 6.93 (\n CI<\/jats:styled-content>\n =5.47 to 8.79) for obese grade\u2010III women. For hypertension, corresponding\n RR<\/jats:styled-content>\n s were 0.86 (\n CI<\/jats:styled-content>\n =0.69 to 1.09), 1.82 (\n CI<\/jats:styled-content>\n =1.67 to 1.98), 2.81 (\n CI<\/jats:styled-content>\n =2.52 to 3.13), 3.92 (\n CI<\/jats:styled-content>\n =3.36 to 4.56), and 5.69 (\n CI<\/jats:styled-content>\n =4.71 to 6.89), and for dyslipidemia,\n RR<\/jats:styled-content>\n s were 1.18 (\n CI<\/jats:styled-content>\n =0.85 to 1.65), 2.01 (\n CI<\/jats:styled-content>\n =1.75 to 2.31), 3.11 (\n CI<\/jats:styled-content>\n =2.61 to 3.70), 4.64 (\n CI<\/jats:styled-content>\n =3.66 to 5.87), and 3.72 (\n CI<\/jats:styled-content>\n =2.53 to 5.48).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this nationwide study of fertile, apparently healthy women, pre\u2010pregnancy\n BMI<\/jats:styled-content>\n was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5\u00a0years following childbirth.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.113.000672","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T04:53:40Z","timestamp":1397192020000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women\u2014A Nationwide Cohort Study"],"prefix":"10.1161","volume":"3","author":[{"given":"Michelle Dalgas","family":"Schmiegelow","sequence":"first","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Sk\u00f8tt","family":"Andersen","sequence":"additional","affiliation":[{"name":"The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Lykke","family":"Norgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Roskilde Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Bo","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark"},{"name":"National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siv Mari","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Institute of Health, Science and Technology, Aalborg University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.39"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1723"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1728"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs174"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.113905"},{"key":"e_1_3_3_8_2","unstructured":"WHO . 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