{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T15:18:14Z","timestamp":1789312694834,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,5,22]]},"abstract":"\n Background<\/jats:title>\n We sought to characterize growth between birth and age 3\u00a0years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37\u00a0weeks gestation (N=498). We determined length\u2010for\u2010age\n z<\/jats:italic>\n score (\n LAZ<\/jats:styled-content>\n ) and weight\u2010for\u2010age\n z<\/jats:italic>\n score (\n WAZ<\/jats:styled-content>\n ) at birth and age 3\u00a0years and change in\n WAZ<\/jats:styled-content>\n over 4 clinically relevant time periods. We identified correlates of change in\n WAZ<\/jats:styled-content>\n and\n LAZ<\/jats:styled-content>\n using multivariable linear regression with bootstrapping. Mean\n WAZ<\/jats:styled-content>\n and\n LAZ<\/jats:styled-content>\n were below average relative to the general population at birth (\n P<\/jats:italic>\n <0.001,\n P<\/jats:italic>\n =0.05, respectively) and age 3\u00a0years (\n P<\/jats:italic>\n <0.001 each). The largest decrease in\n WAZ<\/jats:styled-content>\n occurred between birth and Norwood discharge; the greatest gain occurred between stage\n II<\/jats:styled-content>\n and 14\u00a0months. At age 3\u00a0years,\n WAZ<\/jats:styled-content>\n and\n LAZ<\/jats:styled-content>\n were <\u22122 in 6% and 18%, respectively. Factors associated with change in\n WAZ<\/jats:styled-content>\n differed among time periods. Shunt type was associated with change in\n WAZ<\/jats:styled-content>\n only in the Norwood discharge to stage II period; subjects with a Blalock\u2010Taussig shunt had a greater decline in\n WAZ<\/jats:styled-content>\n than those with a right ventricle\u2010pulmonary artery shunt (\n P<\/jats:italic>\n =0.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n WAZ<\/jats:styled-content>\n changed over time and the predictors of change in\n WAZ<\/jats:styled-content>\n varied among time periods. By age 3\u00a0years, subjects remained small and three times as many children were short as were underweight (>2\n SD<\/jats:styled-content>\n below normal). Failure to find consistent risk factors supports the strategy of tailoring nutritional therapies to patient\u2010 and stage\u2010specific targets.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL:\n http:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n . Unique identifier: NCT00115934.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.000079","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T04:56:40Z","timestamp":1403585800000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Longitudinal Assessment of Growth in Hypoplastic Left Heart Syndrome: Results From the Single Ventricle Reconstruction Trial"],"prefix":"10.1161","volume":"3","author":[{"given":"Phillip T.","family":"Burch","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Utah, Salt Lake City, UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gerstenberger","sequence":"additional","affiliation":[{"name":"New England Research Institutes, Watertown, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Ravishankar","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hehir","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan R.","family":"Davies","sequence":"additional","affiliation":[{"name":"Nemours\/A.I. 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