{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:06:23Z","timestamp":1787652383981,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,3,24]]},"abstract":"\n Background<\/jats:title>\n \n The onset of plastic bronchitis (\n PB<\/jats:styled-content>\n ) can be debilitating in survivors of Fontan surgery. The rarity of this complication makes designing studies to understand risk factors for\n PB<\/jats:styled-content>\n challenging. This 2\u2010center case\u2010control study aimed to describe patient outcomes and to assess the association of antecedent patient factors with\n PB<\/jats:styled-content>\n development.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Using center registries,\n PB<\/jats:styled-content>\n patients (n=25) were matched 1:2 to non\u2010\n PB<\/jats:styled-content>\n Fontans (n=43) by date of Fontan surgery and center. The groups were compared for baseline characteristics. Association of patient characteristics with\n PB<\/jats:styled-content>\n was assessed using logistic regression and of potential risk factors with onset of\n PB<\/jats:styled-content>\n using time\u2010to\u2010event analyses. The median time from Fontan to\n PB<\/jats:styled-content>\n diagnosis was 2.5\u00a0years. Overall, 12\/25\n PB<\/jats:styled-content>\n patients died or underwent heart transplant; the median transplant\u2010free survival was 8.3\u00a0years after diagnosis. Factors associated with developing\n PB<\/jats:styled-content>\n included post\u2010surgical chylothorax (44%\n PB<\/jats:styled-content>\n versus 10% control; odds ratio [\n OR<\/jats:styled-content>\n ] 7.3;\n P<\/jats:italic>\n =0.003), chest tube (\n CT<\/jats:styled-content>\n ) duration at stage 2 (\n P<\/jats:italic>\n =0.04) and Fontan (\n P<\/jats:italic>\n =0.004), and postoperative ascites (36%\n PB<\/jats:styled-content>\n versus 12% control;\n OR<\/jats:styled-content>\n 4.2;\n P<\/jats:italic>\n =0.003).\n CT<\/jats:styled-content>\n drainage >13\u00a0days at Fontan was associated with earlier\n PB<\/jats:styled-content>\n onset (\n P<\/jats:italic>\n =0.04). Early\u2010onset\n PB<\/jats:styled-content>\n was associated with an increased risk of death (\n OR<\/jats:styled-content>\n 5.0;\n P<\/jats:italic>\n =0.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n PB<\/jats:styled-content>\n is a life\u2010threatening disorder. A longer duration of\n CT<\/jats:styled-content>\n drainage after surgery, chylothorax, and development of ascites are all associated with developing\n PB<\/jats:styled-content>\n . Understanding the pathophysiology of peri\u2010operative complications in individual patients and using targeted interventions may delay the onset of the\n PB<\/jats:styled-content>\n phenotype.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.000865","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T06:36:51Z","timestamp":1398235011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":70,"title":["Risk Factors and Outcome of Fontan\u2010Associated Plastic Bronchitis: A Case\u2010Control Study"],"prefix":"10.1161","volume":"3","author":[{"given":"Kurt R.","family":"Schumacher","sequence":"first","affiliation":[{"name":"University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tajinder P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kuebler","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Aprile","sequence":"additional","affiliation":[{"name":"University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D.","family":"Blume","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0430-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2150135112438107"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22673"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.04.043"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181833e8c"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.042"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200102000-00065"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199911)28:5<329::AID-PPUL4>3.0.CO;2-K"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-0913-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.029041"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201209-080OC"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2005.09.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.1031"},{"key":"e_1_3_3_15_2","first-page":"47","article-title":"Successful treatment of plastic bronchitis with low fat diet and subsequent thoracic duct ligation in child with Fontan physiology","volume":"45","author":"Parikh K","year":"2012","unstructured":"Parikh K, Witte MH, Samson R, Teodori M, Carpenter JB, Lowe MC, Morgan W, Hardin C, Brown M, Naughton Y, Sinha S, Barber BJ. Successful treatment of plastic bronchitis with low fat diet and subsequent thoracic duct ligation in child with Fontan physiology. Lymphology. 2012;45:47\u201352.","journal-title":"Lymphology"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.07.004"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070955.55636.25"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.11.005"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2007.00116.x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.114.000865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:30:27Z","timestamp":1715596227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.114.000865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,24]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3,24]]}},"alternative-id":["10.1161\/JAHA.114.000865"],"URL":"https:\/\/doi.org\/10.1161\/jaha.114.000865","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,24]]},"assertion":[{"value":"2014-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e000865"}}