{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:57:42Z","timestamp":1786719462992,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Dickkopf\u20101 (\n              <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n              \u20101) is a major regulator of the Wnt signaling pathway, involved in inflammation, atherogenesis, and the regulation of glucose metabolism. Because platelets are major contributors to circulating levels of\n              <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n              \u20101 in other clinical settings, we aimed at characterizing the platelet contribution to\n              <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n              \u20101 in type 2 diabetes mellitus (T2\n              <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n              ) and evaluating associations of\n              <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n              \u20101 with glucose metabolism, platelet activation, and endothelial dysfunction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A cross\u2010sectional comparison of DKK\u20101, soluble CD40L (\n              <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>\n              40L; reflecting platelet\u2010mediated inflammation), asymmetric dimethylarginine (ADMA; marker of endothelial dysfunction), and urinary 11\u2010dehydro\u2010thromboxane B\n              <jats:sub>2<\/jats:sub>\n              (in vivo marker of platelet activation) was performed among 214 diabetic patients (90 receiving aspirin at 100\u00a0mg\/day) and 30 healthy controls. Plasma DKK\u20101 levels were markedly higher in patients with T2DM than in healthy patients (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). DKK\u20101 levels were significantly lower in diabetic patients receiving compared with those not on aspirin treatment (\n              <jats:italic>P<\/jats:italic>\n              =0.008); in the latter, DKK\u20101 was significantly correlated with 11\u2010dehydro\u2010thromboxane B\n              <jats:sub>2<\/jats:sub>\n              , ADMA, and CD40L (\u03c1=0.303.\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001, \u03c1=0.45.\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001, and \u03c1=0.37,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001, respectively) but not with glycemic control or DM duration. Among patients not receiving aspirin, improvement of metabolic control in a subgroup of newly diagnosed patients treated with acarbose for 20\u00a0weeks and in a group treated with rosiglitazone for 24\u00a0weeks was associated with concurrent significant reductions in DKK\u20101 (\n              <jats:italic>P<\/jats:italic>\n              =0.005 and\n              <jats:italic>P<\/jats:italic>\n              =0.004) and 11\u2010dehydro\u2010thromboxane B\n              <jats:sub>2<\/jats:sub>\n              (\n              <jats:italic>P<\/jats:italic>\n              =0.005 and\n              <jats:italic>P<\/jats:italic>\n              =0.004).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Circulating\n              <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n              \u20101 is increased in T2\n              <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n              and associated with endothelial dysfunction and platelet activation. Plasma\n              <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n              \u20101 levels are reduced with improvement of glycemic control and low\u2010dose aspirin treatment.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.114.001000","type":"journal-article","created":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T05:19:26Z","timestamp":1405747166000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["Circulating Dickkopf\u20101 in Diabetes Mellitus: Association With Platelet Activation and Effects of Improved Metabolic Control and Low\u2010Dose Aspirin"],"prefix":"10.1161","volume":"3","author":[{"given":"Stefano","family":"Lattanzio","sequence":"first","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Santilli","sequence":"additional","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Liani","sequence":"additional","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natale","family":"Vazzana","sequence":"additional","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Di Fulvio","sequence":"additional","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Formoso","sequence":"additional","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Consoli","sequence":"additional","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Dav\u00ec","sequence":"additional","affiliation":[{"name":"Center of Excellence on Aging, \u201cG. d'Annunzio\u201d University of Chieti, 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