{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:11:48Z","timestamp":1792030308517,"version":"4.4.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,9,16]]},"abstract":"\n Background<\/jats:title>\n \n Hypertension is one of the most important risk factors for atrial fibrillation (\n AF<\/jats:styled-content>\n ). Recent studies suggest right atrial remodeling in hypertensive patients may be associated with increased inducibility of\n AF<\/jats:styled-content>\n . This study sought to characterize the electroanatomic features of left and right atria and pulmonary veins (\n PVs<\/jats:styled-content>\n ) in hypertensive patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A prospective observational study was conducted on patients who underwent ablation for paroxysmal supraventricular tachycardia or paroxysmal\n AF<\/jats:styled-content>\n . Electrophysiological features of the\n PV<\/jats:styled-content>\n s and atria, including event\u2010related potentials, conduction time, and inducibility and vulnerability of\n AF<\/jats:styled-content>\n , were characterized during cardiac catheterization. Anatomic and hemodynamic features were assessed by using echocardiographic and computer tomography imaging. When 15 hypertensive patients with paroxysmal supraventricular tachycardia were compared with 17 normotensive patients with paroxysmal supraventricular tachycardia, the hypertensive patients had significantly shortened\n PV<\/jats:styled-content>\n event\u2010related potentials with increased dispersions (\n P<\/jats:italic>\n <0.001) but slightly prolonged atrial event\u2010related potentials (\n P<\/jats:italic>\n =\n NS<\/jats:styled-content>\n ) and had prolonged interatrial and intra\u2010atrial conduction times (\n P<\/jats:italic>\n <0.001). Additionally, the hypertensive patients had increased vulnerability and inducibility of\n AF<\/jats:styled-content>\n and prolonged duration of induced\n AF<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.01). All of these changes were more pronounced in hypertensive patients with paroxysmal\n AF<\/jats:styled-content>\n . Anatomically, compared with the normotensive patients, the diameters of 4\n PV<\/jats:styled-content>\n s in the hypertensive patients with paroxysmal supraventricular tachycardia were significantly enlarged (\n P<\/jats:italic>\n <0.01) and became more remarkable in hypertensive patients with paroxysmal\n AF<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.0001), although the diameter and volume index of the left atrium among 3 groups were similar.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The hypertensive patients showed electroanatomic changes associated with increased vulnerability to\n AF<\/jats:styled-content>\n , including shortened event\u2010related potentials with increased dispersion, prolonged conduction time, and increased\n PV<\/jats:styled-content>\n diameter, but these changes were not appreciated in the atria. Additionally, these changes became more dramatic in hypertensive patients with paroxysmal\n AF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.001033","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T07:41:30Z","timestamp":1411112490000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["The Early Stage of the Atrial Electroanatomic Remodeling as Substrates for Atrial Fibrillation in Hypertensive Patients"],"prefix":"10.1161","volume":"3","author":[{"given":"Xiaomeng","family":"Yin","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China"},{"name":"Texas Heart Institute\/St Luke's Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Dalian Medical 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