{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:17:09Z","timestamp":1793719029448,"version":"4.6.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,9,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Dyslipidemia is a major contributor to the development of atherosclerosis and coronary disease. Its role in the etiology of atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ) is uncertain.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We studied 7142 men and women from the Multi\u2010Ethnic Study of Atherosclerosis (MESA) and the Framingham Heart Study who did not have prevalent AF at baseline and were not on lipid\u2010lowering medications. Total cholesterol, high\u2010density lipoprotein and low\u2010density lipoprotein cholesterol, and triglycerides were measured using standard procedures. Incident AF during follow\u2010up was identified from hospital discharge codes; review of medical charts; study electrocardiograms; and, in MESA only, Medicare claims. Multivariable Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals of AF by clinical categories of blood lipids in each cohort. Study\u2010specific results were meta\u2010analyzed using inverse of variance weighting. During 9.6\u00a0years of mean follow\u2010up, 480 AF cases were identified. In a combined analysis of multivariable\u2010adjusted results from both cohorts, high levels of high\u2010density lipoprotein cholesterol were associated with lower AF risk (hazard ratio 0.64, 95% CI 0.48 to 0.87 in those with levels \u226560\u00a0mg\/dL versus &lt;40\u00a0mg\/dL), whereas high triglycerides were associated with higher risk of AF (hazard ratio 1.60, 95% CI 1.25 to 2.05 in those with levels \u2265200\u00a0mg\/dL versus &lt;150\u00a0mg\/dL). Total cholesterol and low\u2010density lipoprotein cholesterol were not associated with the risk of AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In these 2 community\u2010based cohorts, high\u2010density lipoprotein cholesterol and triglycerides but not low\u2010density lipoprotein cholesterol or total cholesterol were associated with the risk of\n              <jats:styled-content style=\"fixed-case\">AF,<\/jats:styled-content>\n              accounting for other cardiometabolic risk factors.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.114.001211","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T02:53:11Z","timestamp":1412736791000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":124,"title":["Blood Lipids and the Incidence of Atrial Fibrillation: The Multi\u2010Ethnic Study of Atherosclerosis and the Framingham Heart Study"],"prefix":"10.1161","volume":"3","author":[{"given":"Alvaro","family":"Alonso","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University, Boston, MA"},{"name":"NHLBI and Boston University's Framingham Heart Study, Framingham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Roetker","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared W.","family":"Magnani","sequence":"additional","affiliation":[{"name":"NHLBI and Boston University's Framingham Heart Study, Framingham, MA"},{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Kronmal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Ellinor","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA"},{"name":"Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Lubitz","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA"},{"name":"Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"McClelland","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"McManus","sequence":"additional","affiliation":[{"name":"NHLBI and Boston University's Framingham Heart Study, Framingham, MA"},{"name":"Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel R.","family":"Huxley","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Department of Cardiology\/Medicine, Johns Hopkins University, Baltimore, MD"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyses","family":"Szklo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"NHLBI and Boston University's Framingham Heart Study, Framingham, MA"},{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University, Boston, MA"},{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, 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