{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:35:15Z","timestamp":1790058915845,"version":"4.0.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,1,30]]},"abstract":"\n Background<\/jats:title>\n \n Survivors of ventricular fibrillation out of hospital cardiac arrest (\n VF<\/jats:styled-content>\n \u2010\n OHCA<\/jats:styled-content>\n ) due to a potentially reversible cause such as acute myocardial infarction (MI) or ischemia are considered to be at low risk of recurrent arrhythmia. Implantable cardioverter defibrillators (\n ICD<\/jats:styled-content>\n ) are not routinely recommended in such patients. However, the outcome of these patients in the era of rapid coronary revascularization and\n ICD<\/jats:styled-content>\n therapy is not known.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We examined the outcome of 114 consecutive survivors of\n VF OHCA<\/jats:styled-content>\n due to acute\n MI<\/jats:styled-content>\n or ischemia in Olmsted County,\n MN<\/jats:styled-content>\n from 1990 to 2011. An\n ICD<\/jats:styled-content>\n was implanted in 45\/114 patients.\n ICD<\/jats:styled-content>\n recipients had lower\n EF<\/jats:styled-content>\n [median (\n IQR<\/jats:styled-content>\n ) 38 (26 to 54) versus 48 (35 to 58) %,\n P<\/jats:italic>\n =0.04]. During a median (\n IQR<\/jats:styled-content>\n ) follow\u2010up of 9.9 (4.4 to 14.6) years,\n ICD<\/jats:styled-content>\n implantation was associated with reduced cardiac mortality (\n HR<\/jats:styled-content>\n 0.24 [0.07 to 0.88],\n P<\/jats:italic>\n =0.031) and a trend towards reduced all\u2010cause mortality (\n HR<\/jats:styled-content>\n 0.56 [0.30 to 1.02],\n P<\/jats:italic>\n =0.059) after adjusting for the first principal component. One or more appropriate\n ICD<\/jats:styled-content>\n therapies were delivered in 19\/45, with half of the patients receiving therapy within 1\u00a0year. Patients with\n EF<\/jats:styled-content>\n \u226435% at discharge continued to be at long\u2010term risk for\n ICD<\/jats:styled-content>\n therapy compared with those with\n EF<\/jats:styled-content>\n >35% who were at increased risk predominantly in the first 8\u00a0months.\n EF<\/jats:styled-content>\n and revascularization were not significantly associated with\n ICD<\/jats:styled-content>\n therapy in the multivariable analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients with\n VF<\/jats:styled-content>\n \u2010\n OHCA<\/jats:styled-content>\n in the setting of acute\n MI<\/jats:styled-content>\n or myocardial ischemia remain at high risk of recurrent ventricular arrhythmias, particularly if\n EF<\/jats:styled-content>\n \u226435%. This suggests that\n ICD<\/jats:styled-content>\n implantation may be reasonable if\n EF<\/jats:styled-content>\n \u226435%.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.001255","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T12:09:24Z","timestamp":1424952564000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Implantable Cardioverter\u2010Defibrillator Therapy in Patients With Ventricular Fibrillation out of Hospital Cardiac Arrest Secondary to Acute Coronary Syndrome"],"prefix":"10.1161","volume":"4","author":[{"given":"Malini","family":"Madhavan","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhiram","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, St George's University of London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenni S.","family":"Sriram","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Penn State University, Hershey, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Gulati","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e31828124ad"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7047.1633"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197508072930601"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372202"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.11.1297"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.7.748"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.032"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.010"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01597-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80046-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80316-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182340239"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827ca975"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp234"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2476"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00327-7"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.086"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.2.250"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000054211.00668.9B"},{"key":"e_1_3_3_23_2","first-page":"I2","article-title":"Sudden cardiac death. 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