{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:39:35Z","timestamp":1793896775635,"version":"4.8.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,1,30]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data are sparse regarding the impacts of habitual physical activity (PA) and sedentary behavior on cardiovascular (CV) risk in older adults with mobility limitations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study examined the baseline, cross\u2010sectional association between CV risk and objectively measured PA among participants in the Lifestyle Interventions and Independence for Elders (LIFE) study. The relationship between accelerometry measures and predicted 10\u2010year Hard Coronary Heart Disease (HCHD) risk was modeled by using linear regression, stratified according to CVD history. Participants (n=1170, 79\u00b15\u00a0years) spent 642\u00b1111\u00a0min\/day in sedentary behavior (ie, &lt;100 accelerometry counts\/min). They also spent 138\u00b143\u00a0min\/day engaging in PA registering 100 to 499 accelerometry counts\/min and 54\u00b137\u00a0min\/day engaging in PA \u2265500\u00a0counts\/min. Each minute per day spent being sedentary was associated with increased HCHD risk among both those with (0.04%, 95% CI 0.02% to 0.05%) and those without (0.03%, 95% CI 0.02% to 0.03%) CVD. The time spent engaging in activities 100 to 499 as well as \u2265500\u00a0counts\/min was associated with decreased risk among both those with and without CVD (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). The mean number of counts per minute of daily PA was not significantly associated with HCHD risk in any model (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05). However, a significant interaction was observed between sex and count frequency (\n              <jats:italic>P<\/jats:italic>\n              =0.036) for those without CVD, as counts per minute was related to HCHD risk in women (\u03b2=\u22120.94, \u22121.48 to \u22120.41;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) but not in men (\u03b2=\u22120.14, \u22120.59 to 0.88;\n              <jats:italic>P<\/jats:italic>\n              =0.704).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Daily time spent being sedentary is positively associated with predicted 10\u2010year HCHD risk among mobility\u2010limited older adults. Duration, but not intensity (ie, mean counts\/min), of daily PA is inversely associated with HCHD risk score in this population\u2014although the association for intensity may be sex specific among persons without CVD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n              Unique identifier: NCT01072500\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.114.001288","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T17:13:45Z","timestamp":1424366025000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Association of Objectively Measured Physical Activity With Cardiovascular Risk in Mobility\u2010limited Older Adults"],"prefix":"10.1161","volume":"4","author":[{"given":"Jodi D.","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don G.","family":"Hire","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter T.","family":"Ambrosius","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Anton","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Dodson","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Wake Forest University, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Northwestern University, Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe R.","family":"Nocera","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catrine","family":"Tudor\u2010Locke","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel K.","family":"White","sequence":"additional","affiliation":[{"name":"Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Yank","sequence":"additional","affiliation":[{"name":"Stanford University, Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Manini","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Buford","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the LIFE Study Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e31828124ad"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-387"},{"key":"e_1_3_4_4_2","first-page":"114","article-title":"Physical Activity Guidelines Advisory Committee report, 2008. To the Secretary of Health and Human Services","volume":"67","author":"US Department of Health and Human Services","year":"2009","unstructured":"US Department of Health and Human Services . Physical Activity Guidelines Advisory Committee report, 2008. To the Secretary of Health and Human Services. Nutr Rev. 2009;67:114\u2013120.","journal-title":"Nutr Rev"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182456d46"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199910000-00004"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e31815a51b3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.14.1785"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq451"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.156"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086403"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5616"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt064"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr123"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S49737"},{"key":"e_1_3_4_16_2","first-page":"314","article-title":"The modified mini\u2010mental state (3MS) examination","volume":"48","author":"Teng EL","year":"1987","unstructured":"Teng EL, Chui HC. The modified mini\u2010mental state (3MS) examination. J Clin Psychiatry. 1987;48:314\u2013318.","journal-title":"J Clin Psychiatry"},{"key":"e_1_3_4_17_2","first-page":"331","article-title":"Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI)","volume":"14","author":"Buysse DJ","year":"1991","unstructured":"Buysse DJ, Reynolds CF III, Monk TH, Hoch CC, Yeager AL, Kupfer DJ. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep. 1991;14:331\u2013338.","journal-title":"Sleep"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181ed61a3"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.2.180"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_3_4_22_2","first-page":"135","article-title":"Exercise for health. WHO\/FIMS Committee on Physical Activity for Health","volume":"73","author":"Anonymous","year":"1995","unstructured":"Anonymous . Exercise for health. WHO\/FIMS Committee on Physical Activity for Health. Bull World Health Organ. 1995;73:135\u2013136.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437740.48606.d1"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-8-80"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq105"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0493"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181930355"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.019620"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm390"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20110054"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1795"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181607421"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000529"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318288a1e5"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-014-2887-9"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/728289"},{"key":"e_1_3_4_37_2","article-title":"Improvements on cardiovascular diseases risk factors in obese adolescents: a randomized exercise intervention study","author":"Gomes Silva HJ","year":"2014","unstructured":"Gomes Silva HJ, Andersen LB, Lofrano\u2010Prado MC, Barros MVG, Freitas IF Jr, Hill J, do Prado WL. Improvements on cardiovascular diseases risk factors in obese adolescents: a randomized exercise intervention study. J Phys Act Health. 2014. April 17 [Epub ahead of print].","journal-title":"J Phys Act Health"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.1994"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.114.001288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:56:44Z","timestamp":1715594204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.114.001288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1,30]]}},"alternative-id":["10.1161\/JAHA.114.001288"],"URL":"https:\/\/doi.org\/10.1161\/jaha.114.001288","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]},"assertion":[{"value":"2014-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e001288"}}