{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:32:21Z","timestamp":1787959941345,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,12,17]]},"abstract":"\n Background<\/jats:title>\n \n A significant number of implantable cardioverter\u2010defibrillator (\n ICD<\/jats:styled-content>\n ) patients do not experience shocks after\n ICD<\/jats:styled-content>\n implant. Elective generator exchange (\n GE<\/jats:styled-content>\n ) has been associated with increased risk of infection and\n ICD<\/jats:styled-content>\n lead failure. There is a paucity of contemporary data reporting on shock incidence with replacement devices.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Patients undergoing elective\n GE<\/jats:styled-content>\n (n=24\u00a0203) who transmit data remotely via a remote monitoring system were analyzed to determine the incidence of\n ICD<\/jats:styled-content>\n shocks after\n GE<\/jats:styled-content>\n . A total of 16\u00a0230 patients (67%) did not experience a shock with the first\n ICD<\/jats:styled-content>\n (group A), and 7973 (33%) received at least 1 shock (group B). Patients in group A were older (71.3 versus 68.8\u00a0years,\n P<\/jats:italic>\n <0.001) and more often female (71% versus 77% male,\n P<\/jats:italic>\n <0.001). Over an average follow\u2010up of 1.9\u00b11.2\u00a0years after\n GE<\/jats:styled-content>\n , the proportion of patients with shocks and risk of\n ICD<\/jats:styled-content>\n shocks was lower for those who did not receive a shock during the first battery life (group A: 9.9% versus 27.7%, hazard ratio 0.36, 95%\n CI<\/jats:styled-content>\n 0.34 to 0.38,\n P<\/jats:italic>\n <0.001). The cumulative rate of\n ICD<\/jats:styled-content>\n shocks at 5\u00a0years after\n GE<\/jats:styled-content>\n was 25.7% in group A and 51.1% in group B.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this large cohort of\n ICD<\/jats:styled-content>\n patients implanted across the United States, two thirds did not receive\n ICD<\/jats:styled-content>\n shock therapy prior to\n GE<\/jats:styled-content>\n . The occurrence of\n ICD<\/jats:styled-content>\n shocks prior to\n GE<\/jats:styled-content>\n is an important predictor of shocks after\n GE<\/jats:styled-content>\n ; however, even among those without shocks during first battery life, the incidence of shocks at 5\u00a0years following\n GE<\/jats:styled-content>\n is >25%. These data should support informed decision making for patients and physicians at the time of\n ICD<\/jats:styled-content>\n generator end of service.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.001289","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T06:32:15Z","timestamp":1415687535000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Incidence of Defibrillator Shocks After Elective Generator Exchange\u00a0Following Uneventful First Battery Life"],"prefix":"10.1161","volume":"3","author":[{"given":"Faisal M.","family":"Merchant","sequence":"first","affiliation":[{"name":"Cardiology Division, Emory University School of Medicine, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Jones","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation, St. Paul, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Wehrenberg","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation, St. Paul, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Cardiology Division, Emory University School of Medicine, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Saxon","sequence":"additional","affiliation":[{"name":"Cardiology Division, University of Southern California, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.000054"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01111.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.976076"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.959791"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211107"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12248"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1111467"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182618569"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02134.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs177"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.025"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02620.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut301"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960633"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs055"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.083"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2010.08.008"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.561571"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.114.001289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:38:47Z","timestamp":1715596727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.114.001289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,17]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12,17]]}},"alternative-id":["10.1161\/JAHA.114.001289"],"URL":"https:\/\/doi.org\/10.1161\/jaha.114.001289","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,17]]},"assertion":[{"value":"2014-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e001289"}}