{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:36:58Z","timestamp":1793723818056,"version":"4.6.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,12,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Metabolic syndrome (MetS) enhances salt sensitivity of blood pressure and is an important risk factor for cardiovascular disease. The effects of dietary salt restriction on cardiac pathology associated with metabolic syndrome remain unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We investigated whether dietary salt restriction might ameliorate cardiac injury in DahlS.Z\u2010\n              <jats:italic>Lepr<\/jats:italic>\n              <jats:sup>\n                <jats:italic>fa<\/jats:italic>\n              <\/jats:sup>\n              \/\n              <jats:italic>Lepr<\/jats:italic>\n              <jats:sup>\n                <jats:italic>fa<\/jats:italic>\n              <\/jats:sup>\n              (\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese) rats, which are derived from a cross between Dahl salt\u2010sensitive and Zucker rats and represent a model of metabolic syndrome.\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese rats were fed a normal\u2010salt (0.36% NaCl in chow) or low\u2010salt (0.0466% NaCl in chow) diet from 9\u00a0weeks of age and were compared with similarly treated homozygous lean littermates (DahlS.Z\u2010\n              <jats:italic>Lepr<\/jats:italic>\n              <jats:sup>\n                <jats:italic>+<\/jats:italic>\n              <\/jats:sup>\n              \/\n              <jats:italic>Lepr<\/jats:italic>\n              <jats:sup>\n                <jats:italic>+<\/jats:italic>\n              <\/jats:sup>\n              , or\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/lean rats).\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese rats fed the normal\u2010salt diet progressively developed hypertension and showed left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 15\u00a0weeks. Dietary salt restriction attenuated all of these changes in\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese rats. The levels of cardiac oxidative stress and inflammation and the expression of cardiac renin\u2013angiotensin\u2013aldosterone system genes were increased in\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese rats fed the normal\u2010salt diet, and dietary salt restriction downregulated these parameters in both\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese and\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/lean rats. In addition, dietary salt restriction attenuated the increase in visceral adipose tissue inflammation and the decrease in insulin signaling apparent in\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese rats without reducing body weight or visceral adipocyte size. Dietary salt restriction did not alter fasting serum glucose levels but it markedly decreased the fasting serum insulin concentration in\n              <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n              \/obese rats.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Dietary salt restriction not only prevents hypertension and cardiac injury but also ameliorates insulin resistance, without reducing obesity, in this model of metabolic syndrome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.114.001312","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T06:12:20Z","timestamp":1417587140000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Dietary Salt Restriction Improves Cardiac and Adipose Tissue Pathology Independently 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