{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:58:16Z","timestamp":1788919096647,"version":"build-2803163510"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,12,17]]},"abstract":"\n Background<\/jats:title>\n \n We developed risk models for predicting acute kidney injury (\n AKI<\/jats:styled-content>\n ) and\n AKI<\/jats:styled-content>\n requiring dialysis (\n AKI<\/jats:styled-content>\n \u2010D) after percutaneous coronary intervention (\n PCI<\/jats:styled-content>\n ) to support quality assessment and the use of preventative strategies.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n AKI<\/jats:styled-content>\n was defined as an absolute increase of \u22650.3\u00a0mg\/\n dL<\/jats:styled-content>\n or a relative increase of 50% in serum creatinine (\n AKIN<\/jats:styled-content>\n Stage 1 or greater) and\n AKI<\/jats:styled-content>\n \u2010D was a new requirement for dialysis following\n PCI<\/jats:styled-content>\n . Data from 947\u00a0012 consecutive\n PCI<\/jats:styled-content>\n patients and 1253 sites participating in the\n NCDR<\/jats:styled-content>\n Cath\/\n PCI<\/jats:styled-content>\n registry between 6\/09 and 7\/11 were used to develop the model, with 70% randomly assigned to a derivation cohort and 30% for validation.\n AKI<\/jats:styled-content>\n occurred in 7.33% of the derivation and validation cohorts. Eleven variables were associated with\n AKI<\/jats:styled-content>\n : older age, baseline renal impairment (categorized as mild, moderate, and severe), prior cerebrovascular disease, prior heart failure, prior\n PCI<\/jats:styled-content>\n , presentation (non\u2010\n ACS<\/jats:styled-content>\n versus\n NSTEMI<\/jats:styled-content>\n versus\n STEMI<\/jats:styled-content>\n ), diabetes, chronic lung disease, hypertension, cardiac arrest, anemia, heart failure on presentation, balloon pump use, and cardiogenic shock.\n STEMI<\/jats:styled-content>\n presentation, cardiogenic shock, and severe baseline\n CKD<\/jats:styled-content>\n were the strongest predictors for\n AKI<\/jats:styled-content>\n . The full model showed good discrimination in the derivation and validation cohorts (c\u2010statistic of 0.72 and 0.71, respectively) and identical calibration (slope of calibration line=1.01). The\n AKI<\/jats:styled-content>\n \u2010D model had even better discrimination (c\u2010statistic=0.89) and good calibration (slope of calibration line=0.99).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n NCDR AKI<\/jats:styled-content>\n prediction models can successfully risk\u2010stratify patients undergoing\n PCI<\/jats:styled-content>\n . The potential for this tool to aid clinicians in counseling patients regarding the risk of\n PCI<\/jats:styled-content>\n , identify patients for preventative strategies, and support local quality improvement efforts should be prospectively tested.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.001380","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T02:36:34Z","timestamp":1418783794000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":178,"title":["Validated Contemporary Risk Model of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions: Insights From the National Cardiovascular Data Registry Cath\u2010PCI Registry"],"prefix":"10.1161","volume":"3","author":[{"given":"Thomas T.","family":"Tsai","sequence":"first","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO"},{"name":"University of Colorado, Denver, CO"},{"name":"Denver VA Medical Center, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uptal D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara I.","family":"Chang","sequence":"additional","affiliation":[{"name":"Stanford School of Medicine, Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"},{"name":"University of Missouri at Kansas City School of Medicine, Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Masoudi","sequence":"additional","affiliation":[{"name":"University of Colorado, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Matheny","sequence":"additional","affiliation":[{"name":"Tennessee Valley Health System VA, Nashville, TN"},{"name":"Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Kosiborod","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"},{"name":"University of Missouri at Kansas City School of Medicine, Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit P.","family":"Amin","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"},{"name":"University of Missouri at Kansas City School of Medicine, Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Christiana Care Health System, Wilmington, DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeptha P.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Yale School of Medicine, West Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Messenger","sequence":"additional","affiliation":[{"name":"University of Colorado, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Rumsfeld","sequence":"additional","affiliation":[{"name":"University of Colorado, Denver, CO"},{"name":"Denver VA Medical Center, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"},{"name":"University of Missouri at Kansas City School of Medicine, Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.10.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.09.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.056"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02771-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.910638"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr501"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-3-200902030-00006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.3.329"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.068"},{"key":"e_1_3_3_12_2","volume-title":"Crossing the Quality Chasm: A New Health System for the Twenty\u2010first Century","author":"Institute of Medicine","year":"2001","unstructured":"Institute of Medicine . 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