{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:37:02Z","timestamp":1785908222799,"version":"3.56.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Hypertensive disorders of pregnancy are related to higher offspring blood pressure (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              ), but it is not known whether this association strengthens or weakens as\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              changes across childhood. Our aim was to assess the associations of hypertensive disorders of pregnancy and maternal\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              changes during pregnancy with trajectories of offspring\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              from age 7 to 18\u00a0years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a large\n              <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n              cohort of maternal\u2013offspring pairs (N=6619), we used routine antenatal\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              measurements to derive hypertensive disorders of pregnancy and maternal\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              trajectories. These were related to offspring\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              trajectories, obtained from research clinic assessments, using linear spline random\u2010effects models. After adjusting for maternal and offspring variables, including body mass index, offspring of women who had existing hypertension, gestational hypertension, or preeclampsia during pregnancy had on average higher\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              at age 7\u00a0years compared to offspring of normotensive pregnancies (mean difference [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              ] in systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              : 1.67\u00a0mm\u00a0Hg [0.48, 2.86], 1.98\u00a0mm\u00a0Hg [1.32, 2.65], and 1.22\u00a0mm\u00a0Hg [\u22120.52, 2.97], respectively). These differences were consistent across childhood to age 18\u00a0years, as the patterns of\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              change did not differ between offspring of hypertensive pregnancies and normotensive pregnancies. Maternal\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              at 8\u00a0weeks\u2019 gestation was also positively associated with offspring\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              in childhood and adolescence, but changes in\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              across pregnancy were not strongly associated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The differences in\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              between offspring of hypertensive pregnancies and offspring of normotensive pregnancies remain consistent across childhood and adolescence. These associations appear to be most contributed to by higher maternal\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              in early pregnancy rather than by pregnancy\u2010related\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              changes.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.114.001422","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T02:11:14Z","timestamp":1432174274000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Associations of Blood Pressure in Pregnancy With Offspring Blood Pressure Trajectories During Childhood and Adolescence: Findings From a Prospective Study"],"prefix":"10.1161","volume":"4","author":[{"given":"James R.","family":"Staley","sequence":"first","affiliation":[{"name":"Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Silverwood","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Centre for Statistical Methodology London School of Hygiene and Tropical Medicine United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Howe","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of Bristol United Kingdom"},{"name":"School of Social and Community Medicine University of Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Tilling","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of Bristol United Kingdom"},{"name":"School of Social and Community Medicine University of Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie A.","family":"Lawlor","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of Bristol United Kingdom"},{"name":"School of Social and Community Medicine University of Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrie","family":"Macdonald\u2010Wallis","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of Bristol United Kingdom"},{"name":"School of Social and Community Medicine University of Bristol United 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