{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:39:48Z","timestamp":1783082388094,"version":"3.54.6"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,12,17]]},"abstract":"\n Background<\/jats:title>\n \n Multicenter studies on idiopathic or viral pericarditis and pericardial effusion (\n PPE<\/jats:styled-content>\n ) have not been reported in children. Colchicine use for\n PPE<\/jats:styled-content>\n in adults is supported. We explored epidemiology and management for inpatient hospitalizations for\n PPE<\/jats:styled-content>\n in\n US<\/jats:styled-content>\n children and risk factors for readmission.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We analyzed patients in the Pediatric Health Information System database for (1) a code for\n PPE<\/jats:styled-content>\n ; (2) absence of codes for underlying systemic disease (eg, neoplastic, cardiac, rheumatologic, renal); (3) age \u226530\u00a0days and <21\u00a0years; and (4) discharge between January 1, 2007, and December 31, 2012, from 38 hospitals contributing complete data for each year of the study period. Among 11 364 hospitalizations with\n PPE<\/jats:styled-content>\n codes during the study period, 543 (4.8%) met entry criteria for idiopathic or viral\n PPE<\/jats:styled-content>\n . Significantly more boys were noted, especially among adolescents. No temporal trends were noted. Median age was 14.5\u00a0years (interquartile range 7.3 to 16.6\u00a0years); 78 patients (14.4%) underwent pericardiocentesis, 13 (2.4%) underwent pericardiotomy, and 11 (2.0%) underwent pericardiectomy; 157 (28.9%) had an intensive care unit stay, including 2.0% with tamponade. Median hospitalization was 3 days (\n interquartile range<\/jats:styled-content>\n 2 to 4 days). Medications used at initial admission were nonsteroidal anti\u2010inflammatory drugs (71.3%), corticosteroids (22.7%), aspirin (7.0%), and colchicine (3.9%). Readmissions within 1\u00a0year of initial admission occurred in 46 of 447 patients (10.3%), mostly in the first 3\u00a0months. No independent predictors of readmission were noted, but our statistical power was limited. Practice variation was noted in medical management and pericardiocentesis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our report provides the first large multicenter description of idiopathic or viral\n PPE<\/jats:styled-content>\n in children. Idiopathic or viral\n PPE<\/jats:styled-content>\n is most common in male adolescents and is treated infrequently with colchicine.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.001483","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T05:05:05Z","timestamp":1415423105000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["Idiopathic Pericarditis and Pericardial Effusion in Children: Contemporary Epidemiology and Management"],"prefix":"10.1161","volume":"3","author":[{"given":"Divya","family":"Shakti","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hehn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Gauvreau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Sundel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Boston Children's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane W.","family":"Newburger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-007-9014-1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S104795110300026X"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31822251ba"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.542738"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.17.1987"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.02.002"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.04.055"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(18)30334-5"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00778-2"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01514.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119064"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.06.015"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.662114"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.112.965749"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6710"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.08.003"},{"key":"e_1_3_4_18_2","first-page":"432","article-title":"Coxsackievirus B\u20103\u2010induced myocarditis. Effect of sex steroids on viremia and infectivity of cardiocytes","volume":"126","author":"Lyden DC","year":"1987","unstructured":"Lyden DC, Olszewski J, Feran M, Job LP, Huber SA. Coxsackievirus B\u20103\u2010induced myocarditis. Effect of sex steroids on viremia and infectivity of cardiocytes. Am J Pathol. 1987;126:432\u2013438.","journal-title":"Am J Pathol"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208536"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-7-201110040-00359"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.043570"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.114.001483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:39:09Z","timestamp":1715596749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.114.001483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,17]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12,17]]}},"alternative-id":["10.1161\/JAHA.114.001483"],"URL":"https:\/\/doi.org\/10.1161\/jaha.114.001483","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,17]]},"assertion":[{"value":"2014-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e001483"}}