{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:50:23Z","timestamp":1793317823183,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,3,10]]},"abstract":"\n Background<\/jats:title>\n \n The American Heart Association's Life's Simple 7 metric is being used to track the population's cardiovascular health (\n CVH<\/jats:styled-content>\n ) toward a 2020 goal for improvement. The metric includes body mass index (\n BMI<\/jats:styled-content>\n ), blood pressure, cholesterol, glucose, physical activity (\n PA<\/jats:styled-content>\n ), cigarette smoking, and diet. We hypothesized a lower risk of venous thromboembolism (\n VTE<\/jats:styled-content>\n ) with favorable Life's Simple 7 scores.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n REGARDS<\/jats:styled-content>\n recruited 30\u00a0239 black and white participants \u226545 years of age across the United States in 2003\u20132007. A 14\u2010point summary score for Life's Simple 7 classified participants into inadequate (0 to 4 points), average (5 to 9 points), and optimal (10 to 14 points) categories. Hazard ratios (\n HR<\/jats:styled-content>\n s) of incident\n VTE<\/jats:styled-content>\n were calculated for these categories, adjusting for age, sex, race, income, education, and region of residence. For comparison,\n HR<\/jats:styled-content>\n s of\n VTE<\/jats:styled-content>\n were calculated using the Framingham 10\u2010year coronary risk score. There were 263 incident\n VTE<\/jats:styled-content>\n cases over 5.0\u00a0years of follow\u2010up; incidence rates per 1000 person\u2010years declined from 2.9 (95% confidence interval [\n CI<\/jats:styled-content>\n ], 2.3 to 3.7) among those in the inadequate category to 1.8 (95%\n CI<\/jats:styled-content>\n , 1.4 to 2.4) in the optimal category. Compared to the inadequate category, participants in the average category had a 38% lower\n VTE<\/jats:styled-content>\n risk (95%\n CI<\/jats:styled-content>\n , 11 to 57) and participants in the optimal category had a 44% lower risk (95%\n CI<\/jats:styled-content>\n , 18 to 62). The individual score components related to lower\n VTE<\/jats:styled-content>\n risk were ideal\n PA<\/jats:styled-content>\n and\n BMI<\/jats:styled-content>\n . There was no association of Framingham Score with\n VTE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Life's Simple 7, a\n CVH<\/jats:styled-content>\n metric, was associated with reduced\n VTE<\/jats:styled-content>\n risk. Findings suggest that efforts to improve the population's\n CVH<\/jats:styled-content>\n may reduce\n VTE<\/jats:styled-content>\n incidence.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.114.001494","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T03:47:06Z","timestamp":1425095226000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["American Heart Association's Life's Simple 7 and Risk of Venous Thromboembolism: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study"],"prefix":"10.1161","volume":"4","author":[{"given":"Nels C.","family":"Olson","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Vermont College of Medicine, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Cushman","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont College of Medicine, Burlington, VT"},{"name":"Department of Medicine, University of Vermont College of Medicine, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E.","family":"Judd","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"McClure","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan G.","family":"Lakoski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont College of Medicine, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Folsom","sequence":"additional","affiliation":[{"name":"Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika M.","family":"Safford","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Zakai","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont College of Medicine, Burlington, VT"},{"name":"Department of Medicine, University of Vermont College of Medicine, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","volume-title":"The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism","author":"Office of the Surgeon General, National Heart, Lung, and Blood Institute","year":"2008","unstructured":"Office of the Surgeon General, National Heart, Lung, and Blood Institute . Publications and reports of the surgeon general. The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism. 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