{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:38:34Z","timestamp":1789821514693,"version":"4.0.1"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,1,30]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Oxidative stress plays an important role in the pathogenesis of hypertension, especially in obesity\u2010related hypertension. The natriuretic and antinatriuretic components of the renal renin angiotensin system (\n                      <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n                      ) maintain sodium homeostasis and blood pressure. Here, we test the hypothesis that increased oxidative stress leads to the imbalance of\n                      <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n                      components and hypertension in obese Zucker rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Lean and obese rats received vehicle or tempol, a superoxide dismutase mimetic in the drinking water for 4\u00a0weeks. Compared with vehicle\u2010treated lean rats, vehicle\u2010treated obese rats exhibited higher blood pressure and increased renal oxidative stress, accompanied by increased diuretic and natriuretic responses to\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      <jats:sub>1<\/jats:sub>\n                      R antagonist (Candesartan) and\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      <jats:sub>2<\/jats:sub>\n                      R agonist (\n                      <jats:styled-content style=\"fixed-case\">CGP<\/jats:styled-content>\n                      \u201042112A) and reduced diuretic and natriuretic response to MasR agonist (Ang\u2010[1 to 7]). Moreover, obese rats had higher\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      <jats:sub>1<\/jats:sub>\n                      R and\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      <jats:sub>2<\/jats:sub>\n                      R, lower\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      2 and MasR expressions in the kidney. All of the above\u2010mentioned abnormalities were reversed to some degree by tempol treatment. In primary cultures of renal proximal tubular (\n                      <jats:styled-content style=\"fixed-case\">RPT<\/jats:styled-content>\n                      ) cells from lean and obese rats, tempol treatment also increased\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      <jats:sub>2<\/jats:sub>\n                      R,\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      2, and MasR expressions but decreased\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      <jats:sub>1<\/jats:sub>\n                      R and\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      expressions in obese rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Taken together, our study indicated that the imbalance of renal\n                      <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n                      components was associated with increased oxidative stress in obese rats. Furthermore, antioxidant treatment with tempol reversed the imbalance of renal\n                      <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n                      components and led to diuresis and natriuresis, which, at least in part, explains the blood pressure\u2010lowering effect of antioxidant supplementation in obesity\u2010related hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.114.001559","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T23:26:28Z","timestamp":1424129188000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Oxidative Stress Causes Imbalance of Renal Renin Angiotensin System (RAS) Components and Hypertension in Obese Zucker Rats"],"prefix":"10.1161","volume":"4","author":[{"given":"Hao","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaicheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital The Third Military Medical University Chongqing Institute of Cardiology, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.311"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340312803760749"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00075-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/398065"},{"key":"e_1_3_3_6_2","first-page":"39","article-title":"Manifestation of renal disease in obesity: pathophysiology of obesity\u2010related dysfunction of the kidney","volume":"2","author":"D'Elia JA","year":"2009","unstructured":"D'Elia JA, Roshan B, Maski M, Weinrauch LA. 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