{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:27:13Z","timestamp":1773419233315,"version":"3.50.1"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiac resynchronization therapy using bi\u2010ventricular pacing is proven effective in the management of heart failure (HF) with a wide\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              \u2010complex. In the absence of\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              prolongation, however, device\u2010based resynchronization is reported unsuitable. As an alternative, the present study tests a regenerative cell\u2010based approach in the setting of narrow\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              \u2010complex HF.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Progressive cardiac dyssynchrony was provoked in a chronic transgenic model of stress\u2010triggered dilated cardiomyopathy. In contrast to rampant end\u2010stage disease afflicting untreated cohorts, stem cell intervention early in disease, characterized by mechanical dyssynchrony and a narrow\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              \u2010complex, aborted progressive dyssynchronous HF and prevented\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              widening. Stem cell\u2010treated hearts acquired coordinated ventricular contraction and relaxation supporting systolic and diastolic performance. Rescue of contractile dynamics was underpinned by a halted left ventricular dilatation, limited hypertrophy, and reduced fibrosis. Reverse remodeling reflected a restored cardiomyopathic proteome, enforced at systems level through correction of the pathological molecular landscape and nullified adverse cardiac outcomes. Cell therapy of a dyssynchrony\u2010prone cardiomyopathic cohort translated prospectively into improved exercise capacity and prolonged survivorship.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In narrow\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              HF, a regenerative approach demonstrated functional and structural benefit, introducing the prospect of device\u2010autonomous resynchronization therapy for refractory disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.114.001614","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T02:31:57Z","timestamp":1431397917000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy"],"prefix":"10.1161","volume":"4","author":[{"given":"Satsuki","family":"Yamada","sequence":"first","affiliation":[{"name":"Center for Regenerative Medicine, Marriott Heart Disease Research Program Division of Cardiovascular Diseases Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Kent","family":"Arrell","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Marriott Heart Disease Research Program Division of Cardiovascular Diseases Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"Martinez\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Marriott Heart Disease Research Program Division of Cardiovascular Diseases Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atta","family":"Behfar","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Marriott Heart Disease Research Program Division of Cardiovascular Diseases Departments of Medicine, Molecular Pharmacology and 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