{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:49:59Z","timestamp":1784159399848,"version":"3.55.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,7,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiovascular disease and cancer increasingly coexist, yet relationships between cancer and long\u2010term cardiovascular outcomes post\u2013percutaneous coronary intervention (PCI) are not well studied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We examined stented PCI patients at Duke (1996\u20132010) using linked data from the Duke Information Systems for Cardiovascular Care and the Duke Tumor Registry (a cancer treatment registry). Our primary outcome was cardiovascular mortality. Secondary outcomes included composite cardiovascular mortality, myocardial infarction, or repeat revascularization and all\u2010cause mortality. We used adjusted cause\u2010specific hazard models to examine outcomes among cancer patients (cancer treatment pre\u2010PCI) versus controls (no cancer treatment pre\u2010PCI). Cardiovascular mortality was explored in a cancer subgroup with recent (within 1\u00a0year pre\u2010PCI) cancer and in post\u2010PCI cancer patients using post\u2010PCI cancer as a time\u2010dependent variable. Among 15\u00a0008 patients, 3.3% (n=496) were cancer patients. Observed rates of 14\u2010year cardiovascular mortality (31.4% versus 27.7%,\n              <jats:italic>P<\/jats:italic>\n              =0.31) and composite cardiovascular death, myocardial infarction, or revascularization (51.1% versus 55.8%,\n              <jats:italic>P<\/jats:italic>\n              =0.37) were similar for cancer versus control groups; all\u2010cause mortality rates were higher (79.7% versus 49.3%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Adjusted risk of cardiovascular mortality was similar for cancer patients versus controls (hazard ratio 0.95; 95% CI 0.76 to 1.20) and for patients with versus without recent cancer (hazard ratio 1.46; 95% CI 0.92 to 2.33). Post\u2010PCI cancer, present in 4.3% (n=647) of patients, was associated with cardiovascular mortality (adjusted hazard ratio 1.51; 95% CI 1.11 to 2.03).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Cancer history was present in a minority of PCI patients but was not associated with worse long\u2010term cardiovascular outcomes. Further investigation into PCI outcomes in this population is warranted.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.001779","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T02:09:47Z","timestamp":1436234987000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":71,"title":["Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"4","author":[{"given":"Connie N.","family":"Hess","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC"},{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Roe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC"},{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Clare","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Chiswell","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kelly","sequence":"additional","affiliation":[{"name":"Center for Learning Healthcare, Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Tcheng","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC"},{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Hagstrom","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel G.","family":"Khouri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford R.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"},{"name":"Duke Cancer Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Kong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC"},{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P.","family":"Abernethy","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC"},{"name":"Center for Learning Healthcare, Duke Clinical Research Institute, Durham, NC"},{"name":"Duke Cancer Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell W.","family":"Krucoff","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC"},{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ba622"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.005"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.11.036"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.08.026"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.3.263"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.09.042"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.066969"},{"key":"e_1_3_5_9_2","unstructured":"World Health Organization . 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