{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:34:24Z","timestamp":1792654464632,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,4,22]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recent evidence suggests that left atrial (LA) dysfunction may be mechanistically contributing to cerebrovascular events in patients with atrial fibrillation (AF). We investigated the association between regional LA function and a prior history of stroke during sinus rhythm in patients referred for catheter ablation of AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 169 patients (59\n              <jats:bold>\u00b1<\/jats:bold>\n              10\u00a0years, 74% male, 29% persistent AF) with a history of AF in sinus rhythm at the time of pre\u2010ablation cardiac magnetic resonance (CMR) were analyzed. The LA volume, emptying fraction, strain (S), and strain rate (SR) were assessed by tissue\u2010tracking cardiac magnetic resonance. The patients with a history of stroke or transient ischemic attack (n=18) had greater LA volumes (V\n              <jats:sub>max<\/jats:sub>\n              and V\n              <jats:sub>min<\/jats:sub>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.02 and\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001, respectively), lower LA total emptying fraction (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), lower LA maximum and pre\u2010atrial contraction strains (S\n              <jats:sub>max<\/jats:sub>\n              and S\n              <jats:sub>preA<\/jats:sub>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 and\n              <jats:italic>P<\/jats:italic>\n              =0.01, respectively), and lower absolute values of LA SR during left ventricular (LV) systole and early diastole (SR\n              <jats:sub>s<\/jats:sub>\n              and SR\n              <jats:sub>e<\/jats:sub>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.005 and 0.03, respectively) than those without stroke\/transient ischemic attack (n=151). Multivariable analysis demonstrated that the LA reservoir function, including total emptying fraction, S\n              <jats:sub>max<\/jats:sub>\n              , and SR\n              <jats:sub>s<\/jats:sub>\n              , was associated with stroke\/transient ischemic attack (odds ratio 0.94, 0.91, and 0.17;\n              <jats:italic>P<\/jats:italic>\n              =0.03, 0.02, and 0.04, respectively) after adjusting for the CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc score and LA V\n              <jats:sub>min<\/jats:sub>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Depressed LA reservoir function assessed by tissue\u2010tracking cardiac magnetic resonance is significantly associated with a prior history of stroke\/transient ischemic attack in patients with AF. Our findings suggest that assessment of LA reservoir function can improve the risk stratification of cerebrovascular events in AF patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.001844","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T01:23:32Z","timestamp":1430184212000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Quantitative Tissue\u2010Tracking Cardiac Magnetic Resonance (CMR) of Left Atrial Deformation and the Risk of Stroke in Patients With Atrial Fibrillation"],"prefix":"10.1161","volume":"4","author":[{"given":"Yuko Y.","family":"Inoue","sequence":"first","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alissa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan M.","family":"Khurram","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadali","family":"Habibi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath A.","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan L.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"},{"name":"Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D.","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"},{"name":"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Calkins","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao A.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ashikaga","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"},{"name":"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000152"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp038123"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.835"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.02.021"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.10.019"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002769"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.01.016"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.03.010"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000041"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.01.016"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131971"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.12.005"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.02.016"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.10.007"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.05.040"},{"key":"e_1_3_5_19_2","first-page":"213","article-title":"Left atrial volume quantification using cardiac MRI in atrial fibrillation: comparison of the Simpson's method with biplane area\u2010length, ellipse, and three\u2010dimensional methods","volume":"19","author":"Nacif MS","year":"2013","unstructured":"Nacif MS, Barranhas AD, Turkbey E, Marchiori E, Kawel N, Mello RA, Falcao RO, Oliveira AC Jr, Rochitte CE. 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