{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:58:24Z","timestamp":1782979104098,"version":"3.54.5"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,7,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We determined whether poorer 6\u2010minute walk performance and lower physical activity levels are associated with higher rates of ischemic heart disease (\n              <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>\n              ) events in people with lower extremity peripheral artery disease (\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Five hundred ten\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              participants were identified from Chicago\u2010area medical centers and followed prospectively for 19.0\u00b19.5\u00a0months. At baseline, participants completed the 6\u2010minute walk and reported number of blocks walked during the past week (physical activity).\n              <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>\n              events were systematically adjudicated and consisted of new myocardial infarction, unstable angina, and cardiac death. For 6\u2010minute walk, IHD event rates were 25\/170 (14.7%) for the third (poorest) tertile, 10\/171 (5.8%%) for the second tertile, and 6\/169 (3.5%) for the first (best) tertile (\n              <jats:italic>P<\/jats:italic>\n              =0.003). For physical activity, IHD event rates were 21\/154 (13.6%) for the third (poorest) tertile, 15\/174 (8.6%) for the second tertile, and 5\/182 (2.7%) for the first (best) tertile (\n              <jats:italic>P<\/jats:italic>\n              =0.001). Adjusting for age, sex, race, smoking, body mass index, comorbidities, and physical activity, participants in the poorest 6\u2010minute walk tertile had a 3.28\u2010fold (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.17 to 9.17,\n              <jats:italic>P<\/jats:italic>\n              =0.024) higher hazard for\n              <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>\n              events, compared with those in the best tertile. Adjusting for confounders including 6\u2010minute walk, participants in the poorest physical activity tertile had a 3.72\u2010fold (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.24 to 11.19,\n              <jats:italic>P<\/jats:italic>\n              =0.019) higher hazard for\n              <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>\n              events, compared with the highest tertile.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Six\u2010minute walk and physical activity predict\n              <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>\n              event rates in\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              . Further study is needed to determine whether interventions that improve 6\u2010minute walk, physical activity, or both can reduce\n              <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>\n              events in\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.001846","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T02:10:20Z","timestamp":1438135820000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Association of 6\u2010Minute Walk Performance and Physical Activity With Incident Ischemic Heart Disease Events and Stroke in Peripheral Artery Disease"],"prefix":"10.1161","volume":"4","author":[{"given":"Mary M.","family":"McDermott","sequence":"first","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Greenland","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy, Stanford University, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina R.","family":"Kibbe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Jesse Brown Veterans Affairs Medical Center, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Criqui","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"National Institute on Aging, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Huffman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lloyd\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000442015.53336.12"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.03.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.2.197"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.13.1599"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-12-200206180-00008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.4.453"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.063"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2014.03.009"},{"key":"e_1_3_3_11_2","volume-title":"The Women's Health and Aging Study: Health and Social Characteristics of Older Women With Disability","author":"Fried LP","year":"1995","unstructured":"Fried LP, Kasper JD, Williamson JD, Skinner EA, Morris CD, Hochberg MC; for the Disease Ascertainment Working Group . Disease ascertainment algorithms. Disease ascertainment algorithms. In: Guralnik JM, Fried LP, Simonsick EM, Kasper JD, Lafferty ME, eds. The Women's Health and Aging Study: Health and Social Characteristics of Older Women With Disability. Bethesda, MD: National Institute on Aging ; 1995. Appendix E. NIH Pub. NO. 95\u20104009."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.108640"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.007002"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.05.030"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.12.034"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116387"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53103.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00462-0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.605246"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.791491"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00041-0"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5616"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00524-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2018"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.07.051"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000435708.67487.da"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.962"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.7231"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.001846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:46:16Z","timestamp":1715597176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.001846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,17]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7,17]]}},"alternative-id":["10.1161\/JAHA.115.001846"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.001846","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,17]]},"assertion":[{"value":"2015-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e001846"}}