{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:56:55Z","timestamp":1779879415450,"version":"3.53.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,5]]},"abstract":"\n Background<\/jats:title>\n \n The characteristics of patients undergoing atrial fibrillation (\n AF<\/jats:styled-content>\n ) ablation and subsequent outcomes in community practice are not well described.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Using the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (\n ORBIT<\/jats:styled-content>\n \u2010\n AF<\/jats:styled-content>\n ), we investigated the prevalence and impact of catheter ablation of\n AF<\/jats:styled-content>\n . Among 9935 patients enrolled, 5.3% had previous\n AF<\/jats:styled-content>\n ablation. Patients with\n AF<\/jats:styled-content>\n ablation were significantly younger, more frequently male, and had less anemia, chronic obstructive pulmonary disease, and previous myocardial infarction (P<0.05 for all analyses) than those without previous catheter ablation of\n AF<\/jats:styled-content>\n . Ablated patients were more likely to have a family history of\n AF<\/jats:styled-content>\n , obstructive sleep apnea, paroxysmal\n AF<\/jats:styled-content>\n , and moderate\u2010to\u2010severe symptoms (P<0.0001 for all analyses). Patients with previous ablation were more often in sinus rhythm on entry into the registry (52% vs. 32%; P<0.0001). Despite previous ablation, 46% in the ablation group were still on antiarrhythmic therapy. Oral anticoagulation was prescribed in 75% of those with previous ablation versus 76% in those without previous ablation (P=0.5). The adjusted risk of death (hazard ratio [\n HR<\/jats:styled-content>\n ], 0.78; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 0.52 to 1.18; P=0.2) and cardiovascular (\n CV<\/jats:styled-content>\n ) hospitalization (\n HR<\/jats:styled-content>\n , 1.06; 95%\n CI<\/jats:styled-content>\n , 0.90 to 1.26; P=0.5) were similar in both groups. Patients with incident\n AF<\/jats:styled-content>\n ablation had higher risk of subsequent\n CV<\/jats:styled-content>\n hospitalization than matched patients without incident ablation (\n HR<\/jats:styled-content>\n , 1.67; 95%\n CI<\/jats:styled-content>\n , 1.24 to 2.26; P=0.0008).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In U.S. clinical practice, a minority of patients with\n AF<\/jats:styled-content>\n are managed with catheter ablation. Subsequent to ablation, there were no significant differences in oral anticoagulation use or outcomes, including stroke\/non\u2013central nervous system embolism\/transient ischemic attack or death.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 01165710.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.001901","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T01:55:31Z","timestamp":1432259731000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Catheter Ablation of Atrial Fibrillation in U.S. Community Practice\u2014Results From Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT\u2010AF)"],"prefix":"10.1161","volume":"4","author":[{"given":"Fredrik","family":"Holmqvist","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DaJuanicia","family":"Simon","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Jae","family":"Hong","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Kowey","sequence":"additional","affiliation":[{"name":"Lankenau Hospital and Medical Research Center Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Reiffel","sequence":"additional","affiliation":[{"name":"Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald V.","family":"Naccarelli","sequence":"additional","affiliation":[{"name":"Penn State Milton S. Hershey Medical Center Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chang","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceuticals, Inc Raritan NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ORBIT\u2010AF Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.859116"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000041"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.856633"},{"key":"e_1_3_1_5_2","first-page":"CD007101","article-title":"Catheter ablation for paroxysmal and persistent atrial fibrillation","volume":"4","author":"Chen HS","year":"2012","unstructured":"Chen HS, Wen JM, Wu SN, Liu JP. 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