{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:54:40Z","timestamp":1768881280522,"version":"3.49.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,6,15]]},"abstract":"\n Background<\/jats:title>\n \n Proprotein convertase subtilisin\/kexin9 (\n PCSK<\/jats:styled-content>\n 9) monoclonal antibody significantly reduces low\u2010density lipoprotein cholesterol level in patients with hypercholesterolemia. The goal of this study was to review recently reported randomized controlled trials to investigate the therapeutic effects and safety of\n PCSK<\/jats:styled-content>\n 9 inhibitors.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The clinical randomized controlled trials published from inception to March 19, 2015 were identified from The Cochrane Library databases,\n PUBMED<\/jats:styled-content>\n , and\n EBASE<\/jats:styled-content>\n . Randomized controlled trials of at least 8\u00a0weeks duration using\n PCSK<\/jats:styled-content>\n 9 inhibitors in treating patients with hypercholesterolemia were included. Mean difference (\n MD<\/jats:styled-content>\n ) with a 95%\n CI<\/jats:styled-content>\n was used to calculate the continuous data, the standardized mean difference with a 95%\n CI<\/jats:styled-content>\n was used when the unit was not unified, and risk ratio with a 95%\n CI<\/jats:styled-content>\n was used for dichotomous data. After screening, 20 trials fulfilled the inclusion criteria.\n PCSK<\/jats:styled-content>\n 9 inhibitors significantly decreased the levels of low\u2010density lipoprotein cholesterol (\n MD<\/jats:styled-content>\n =\u221265.29\u00a0mg\/dL, 95%\n CI<\/jats:styled-content>\n : \u221272.08 to \u221258.49), total cholesterol (\n MD<\/jats:styled-content>\n =\u221260.04\u00a0mg\/dL, 95%\n CI<\/jats:styled-content>\n : \u221269.95 to \u221250.13), triglycerides (\n MD<\/jats:styled-content>\n =\u221212.21\u00a0mg\/dL, 95%\n CI<\/jats:styled-content>\n : \u221216.21 to \u22128.22) and apolipoprotein\u2010B (\n MD<\/jats:styled-content>\n =\u221241.01\u00a0mg\/dL, 95%\n CI<\/jats:styled-content>\n : \u221246.07 to \u221235.94), lipoprotein(a) (standardized mean difference=\u22120.94, 95%\n CI<\/jats:styled-content>\n : \u22121.12 to \u22120.77) and increased the levels of high\u2010density lipoprotein cholesterol (\n MD<\/jats:styled-content>\n =3.40\u00a0mg\/dL, 95%\n CI<\/jats:styled-content>\n : 3.12 to 3.68) and apolipoprotein\u2010A1 (\n MD<\/jats:styled-content>\n =6.75\u00a0mg\/dL, 95%\n CI<\/jats:styled-content>\n : 4.64 to 8.86). There was no significant difference in the incidence of treatment\u2010emergent adverse events (risk ratio=1.01, 95%\n CI<\/jats:styled-content>\n : 0.98 to 1.04), serious treatment\u2010emergent adverse events (risk ratio=1.01, 95%\n CI<\/jats:styled-content>\n : 0.88 to 1.17), and the discontinuation of treatment between the 2 groups (risk ratio=1.07, 95%\n CI<\/jats:styled-content>\n : 0.86 to 1.34).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The meta\u2010analysis indicated that\n PCSK<\/jats:styled-content>\n 9 inhibitors had a strong effect in lowering low\u2010density lipoprotein cholesterol and other lipid levels with satisfactory safety and tolerability in patients with hypercholesterolemia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.001937","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T02:50:54Z","timestamp":1434423054000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Efficiency and Safety of Proprotein Convertase Subtilisin\/Kexin 9 Monoclonal Antibody on Hypercholesterolemia: A Meta\u2010Analysis of 20 Randomized Controlled Trials"],"prefix":"10.1161","volume":"4","author":[{"given":"Chuanwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, 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