{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:16:32Z","timestamp":1791818192553,"version":"4.3.4"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,5]]},"abstract":"\n Background<\/jats:title>\n \n Coronary artery aneurysms (\n CAA<\/jats:styled-content>\n ) are serious complications of Kawasaki disease (\n KD<\/jats:styled-content>\n ). Optical coherence tomography (\n OCT<\/jats:styled-content>\n ) is a high\u2010resolution intracoronary imaging modality that characterizes coronary artery wall structure. The purpose of this work was to describe\n CAA<\/jats:styled-content>\n wall sequelae after\n KD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n KD<\/jats:styled-content>\n patients scheduled for routine coronary angiography underwent\n OCT<\/jats:styled-content>\n imaging between March 2013 and August 2014. Subjects\u2019 clinical courses, echocardiography, and coronary angiography examinations were reviewed retrospectively.\n OCT<\/jats:styled-content>\n was performed in 18 patients aged 12.4\u00b15.5\u00a0years, 9.0\u00b15.1\u00a0years following onset of\n KD<\/jats:styled-content>\n . Of those, 14 patients (77.7%) had a history of\n CAA<\/jats:styled-content>\n (7 with giant\n CAA<\/jats:styled-content>\n and 7 with regressed\n CAA<\/jats:styled-content>\n at time of\n OCT<\/jats:styled-content>\n ). Intracoronary nitroglycerin was given to all patients (88.4\u00b145.5\u00a0\u03bcg\/m\n 2<\/jats:sup>\n ). Mean radiation dose was 10.9\u00b15.2\u00a0\n mG<\/jats:styled-content>\n y\/kg. One patient suffered from a transitory uneventful vasospasm at the site of a regressed\n CAA<\/jats:styled-content>\n ; otherwise no major procedural complications occurred. The most frequent abnormality observed on\n OCT<\/jats:styled-content>\n was intimal hyperplasia (15 patients, 83.3%) seen at both aneurysmal sites and angiographically normal segments amounting to 390.8\u00b1166.0\u00a0\u03bcm for affected segments compared to 61.7\u00b117\u00a0\u03bcm for unaffected segments (\n P<\/jats:italic>\n <0.001). Disappearance of the media, and presence of fibrosis, calcifications, macrophage accumulation, neovascularization, and white thrombi were seen in 72.2%, 77.8%, 27.8%, 44.4%, and 33.3% of patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this study,\n OCT<\/jats:styled-content>\n proved safe and insightful in the setting of\n KD<\/jats:styled-content>\n , with the potential to add diagnostic value in the assessment of coronary abnormalities in\n KD<\/jats:styled-content>\n . The depicted coronary structural changes correspond to histological findings previously described in\n KD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.001939","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T22:01:10Z","timestamp":1432072870000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Coronary Wall Structural Changes in Patients With Kawasaki Disease: New Insights From Optical Coherence Tomography (OCT)"],"prefix":"10.1161","volume":"4","author":[{"given":"Audrey","family":"Dionne","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragui","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"},{"name":"Division of Cardiology Pierre Boucher Hospital Longueuil Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gebhard","sequence":"additional","affiliation":[{"name":"Division of Cardiology Montreal Heart Institute Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bakloul","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"},{"name":"Division of Pediatric Cardiology Louis Pradel Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Bernard","family":"Selly","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"},{"name":"Division of Pediatric Cardiology CHU Bordeaux Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Leye","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"D\u00e9ry","sequence":"additional","affiliation":[{"name":"Division of Radiology CHU Ste\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantale","family":"Lapierre","sequence":"additional","affiliation":[{"name":"Division of Radiology CHU Ste\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Girard","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fournier","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagib","family":"Dahdah","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology CHU Sainte\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2182"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-74-0903"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.818609"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01175-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00447-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.079"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001764"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038998"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.04.028"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.11.084"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.102"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-010-9712-y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.3.307"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2007.09.001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.25.2935"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002460010180"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22273"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.06.019"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I1A14"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV6I5A97"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.001939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:34:38Z","timestamp":1715582078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.001939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1161\/JAHA.115.001939"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.001939","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"2015-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e001939"}}