{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:56:27Z","timestamp":1791276987331,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,9,16]]},"abstract":"\n Background<\/jats:title>\n Preclinical data suggest that an acute inflammatory response following myocardial infarction (MI) accelerates systemic atherosclerosis. Using combined positron emission and computed tomography, we investigated whether this phenomenon occurs in humans.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Overall, 40 patients with MI and 40 with stable angina underwent thoracic 18F\u2010fluorodeoxyglucose combined positron emission and computed tomography scan. Radiotracer uptake was measured in aortic atheroma and nonvascular tissue (paraspinal muscle). In 1003 patients enrolled in the Global Registry of Acute Coronary Events, we assessed whether infarct size predicted early (\u226430\u00a0days) and late (>30\u00a0days) recurrent coronary events. Compared with patients with stable angina, patients with MI had higher aortic 18F\u2010fluorodeoxyglucose uptake (tissue\u2010to\u2010background ratio 2.15\u00b10.30 versus 1.84\u00b10.18,\n P<\/jats:italic>\n <0.0001) and plasma C\u2010reactive protein concentrations (6.50 [2.00 to 12.75] versus 2.00 [0.50 to 4.00] mg\/dL,\n P<\/jats:italic>\n =0.0005) despite having similar aortic (\n P<\/jats:italic>\n =0.12) and less coronary (\n P<\/jats:italic>\n =0.006) atherosclerotic burden and similar paraspinal muscular 18F\u2010fluorodeoxyglucose uptake (\n P<\/jats:italic>\n =0.52). Patients with\n ST<\/jats:styled-content>\n \u2010segment elevation MI had larger infarcts (peak plasma troponin 32\u00a0300 [10\u00a0200 to >50\u00a0000] versus 3800 [1000 to 9200] ng\/L,\n P<\/jats:italic>\n <0.0001) and greater aortic 18F\u2010fluorodeoxyglucose uptake (2.24\u00b10.32 versus 2.02\u00b10.21,\n P<\/jats:italic>\n =0.03) than those with non\u2013\n ST<\/jats:styled-content>\n \u2010segment elevation MI. Peak plasma troponin concentrations correlated with aortic 18F\u2010fluorodeoxyglucose uptake (\n r<\/jats:italic>\n =0.43,\n P<\/jats:italic>\n =0.01) and, on multivariate analysis, independently predicted early (tertile 3 versus tertile 1: relative risk 4.40 [95% CI 1.90 to 10.19],\n P<\/jats:italic>\n =0.001), but not late, recurrent MI.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The presence and extent of MI is associated with increased aortic atherosclerotic inflammation and early recurrent MI. This finding supports the hypothesis that acute MI exacerbates systemic atherosclerotic inflammation and remote plaque destabilization: MI begets MI.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier: NCT01749254.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.001956","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T02:10:07Z","timestamp":1440727807000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["Systemic Atherosclerotic Inflammation Following Acute Myocardial Infarction: Myocardial Infarction Begets Myocardial Infarction"],"prefix":"10.1161","volume":"4","author":[{"given":"Nikhil V.","family":"Joshi","sequence":"first","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Toor","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop S. V.","family":"Shah","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Carruthers","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex T.","family":"Vesey","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirjel R.","family":"Alam","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sills","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng Y.","family":"Hoo","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Melville","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah P.","family":"Langlands","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S. A.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal G.","family":"Uren","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Mills","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Clinical Research Imaging Centre, University of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J. 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