{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:06:20Z","timestamp":1776128780924,"version":"3.50.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,7,17]]},"abstract":"\n Background<\/jats:title>\n \n Mild transverse aortic arch (\n TAA<\/jats:styled-content>\n ) hypoplasia is common after coarctation treatment, but is considered benign in the absence of an arm\u2010leg systolic blood pressure (\n SBP<\/jats:styled-content>\n ) difference. Hypertension (HTN) is a common long\u2010term morbidity after successful coarctation treatment. We examined whether mild\n TAA<\/jats:styled-content>\n hypoplasia after coarctation treatment is associated with late systemic HTN.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We retrospectively reviewed 92 patients (median age, 19.9\u00a0years; range, 4.9 to 57.8; 60% male) 14.1\u00b110.3\u00a0years after successful coarctation treatment (surgery in 63, stent in 16, and balloon dilation in 13), excluding those with resting right arm\u2010leg blood pressure gradient >20\u00a0mm\u00a0Hg, atypical coarctation, and major associated heart defects. Minimum body\u2010surface area (\n BSA<\/jats:styled-content>\n )\u2010adjusted\n TAA<\/jats:styled-content>\n cross\u2010sectional area (\n CSA<\/jats:styled-content>\n ) was calculated from cardiac magnetic resonance (CMR) images. On follow\u2010up, 38 of 92 (41%) patients had systemic HTN using standard criteria. Systemic HTN was independently associated with smaller\n TAA CSA<\/jats:styled-content>\n \/\n BSA<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.006; odds ratio [OR], 6.41 per 0.5\u00a0cm\n 2<\/jats:sup>\n \/m\n 2<\/jats:sup>\n decrease), higher age at\n CMR<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.03; OR, 1.57 per 5\u2010year increase), and in a subset (n=61), higher arm\u2010leg\n SBP<\/jats:styled-content>\n difference during exercise (\n P<\/jats:italic>\n =0.05; OR, 1.03 per 1\u2010mm\u2010Hg increase). Lower ratio of\n TAA<\/jats:styled-content>\n diameter\/descending aorta diameter was associated with a larger increase in right arm\n SBP<\/jats:styled-content>\n during peak exercise (\n P<\/jats:italic>\n =0.006;\n r<\/jats:italic>\n 2<\/jats:sup>\n =0.11).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Persistent mild aortic arch hypoplasia, even in the absence of an arm\u2010leg\n SBP<\/jats:styled-content>\n difference at rest, is associated with late systemic HTN. Further studies should be undertaken to determine whether more\u2010aggressive arch reconstruction at initial repair can reduce the incidence of systemic HTN.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.001978","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T04:35:42Z","timestamp":1435293342000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Persistent Aortic Arch Hypoplasia After Coarctation Treatment Is Associated With Late Systemic Hypertension"],"prefix":"10.1161","volume":"4","author":[{"given":"Sophie","family":"Quennelle","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Geva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, 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