{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:53:29Z","timestamp":1768776809043,"version":"3.49.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,7,17]]},"abstract":"\n Background<\/jats:title>\n \n Previous studies have shown conflicting results regarding the benefit of cardiac resynchronization therapy (\n CRT<\/jats:styled-content>\n ) by sex and\n QRS<\/jats:styled-content>\n duration.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (\n MADIT<\/jats:styled-content>\n \u2010\n CRT<\/jats:styled-content>\n ), we evaluated long\u2010term clinical outcome of heart failure (\n HF<\/jats:styled-content>\n ) or death, death, and\n HF<\/jats:styled-content>\n alone by sex and\n QRS<\/jats:styled-content>\n duration (dichotomized at 150\u00a0ms) in left bundle\u2010branch block patients with\n CRT<\/jats:styled-content>\n with defibrillator backup (\n CRT<\/jats:styled-content>\n \u2010D) versus implantable cardioverter\u2010defibrillator (\n ICD<\/jats:styled-content>\n ) only. There were 394 women (31%) and 887 men with left bundle\u2010branch block. During the median follow\u2010up of 5.6 years, women derived greater clinical benefit from\n CRT<\/jats:styled-content>\n \u2010D compared with implantable cardioverter\u2010defibrillator only, with a significant 71% reduction in\n HF<\/jats:styled-content>\n or death (hazard ratio [\n HR<\/jats:styled-content>\n ] 0.29,\n P<\/jats:italic>\n <0.001) and a 77% reduction in\n HF<\/jats:styled-content>\n alone (\n HR<\/jats:styled-content>\n 0.23,\n P<\/jats:italic>\n <0.001) compared with men, who had a 41% reduction in\n HF<\/jats:styled-content>\n or death (\n HR<\/jats:styled-content>\n 0.59,\n P<\/jats:italic>\n <0.001) and a 50% reduction in\n HF<\/jats:styled-content>\n alone (\n HR<\/jats:styled-content>\n 0.50,\n P<\/jats:italic>\n <0.001) (all sex\u2010by\u2010treatment interaction\n P<\/jats:italic>\n <0.05). Men and women had similar reduction in long\u2010term mortality with\n CRT<\/jats:styled-content>\n \u2010D versus implantable cardioverter\u2010defibrillator only (men:\n HR<\/jats:styled-content>\n 0.70,\n P<\/jats:italic>\n =0.03; women:\n HR<\/jats:styled-content>\n 0.59,\n P<\/jats:italic>\n =0.04). The incremental benefit of\n CRT<\/jats:styled-content>\n \u2010D in women for\n HF<\/jats:styled-content>\n or death and\n HF<\/jats:styled-content>\n alone was consistent with\n QRS<\/jats:styled-content>\n <150 or >150\u00a0ms.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n During long\u2010term follow\u2010up of mild\n HF<\/jats:styled-content>\n patients with left ventricular dysfunction and wide\n QRS<\/jats:styled-content>\n , both women and men with left bundle\u2010branch block derived sustained benefit from\n CRT<\/jats:styled-content>\n \u2010D versus implantable cardioverter\u2010defibrillator only, with significant reduction in\n HF<\/jats:styled-content>\n or death,\n HF<\/jats:styled-content>\n alone, and all\u2010cause mortality regardless of\n QRS<\/jats:styled-content>\n duration. There is an incremental benefit with\n CRT<\/jats:styled-content>\n \u2010D in women for the end points of\n HF<\/jats:styled-content>\n or death and\n HF<\/jats:styled-content>\n alone.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL:\n https:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n . Unique identifiers: NCT00180271, NCT01294449, and NCT02060110.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002013","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T19:04:02Z","timestamp":1536951842000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Sex Differences in Long\u2010Term Outcomes With Cardiac Resynchronization Therapy in Mild Heart Failure Patients With Left Bundle Branch Block"],"prefix":"10.1161","volume":"4","author":[{"given":"Yitschak","family":"Biton","sequence":"first","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Klein","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronislava","family":"Polonsky","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur J.","family":"Moss","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the MADIT\u2010CRT Executive Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.061"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960898"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401426"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1162"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.04.001"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2005.00073.x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq027"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.12.014"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht290"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2012.12.003"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.059"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.2717"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095027.28753.9D"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84882-046-3"}],"container-title":["Journal of the American Heart 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