{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:27:48Z","timestamp":1790400468911,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,6,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Isolated nocturnal hypertension (\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              ) has been studied among the general population and hypertensive patients. However, little insight is available on the prevalence of\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              and its role in target\u2010organ damage among patients with chronic kidney disease (CKD).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We recruited 1282\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              patients admitted to our hospital division. Patients were divided into 4 groups:\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              ; isolated daytime hypertension; day\u2013night sustained; and ambulatory normotension. Multiple linear regression analyses were used to evaluate the correlation between\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              and renal\/cardiovascular parameters. A total of 262 (20.44%)\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              patients had isolated nocturnal hypertension and 651 (50.78%) had day\u2013night sustained hypertension, whereas only 350 (27.30%) patients showed normotension and 19 (1.48%) had isolated daytime hypertension. Multivariate logistic regression analysis showed that\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              was associated mainly with age, estimated glomerular filtration rate, clinic diastolic blood pressure, and that\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              was determined only by age, estimated glomerular filtration rate, and clinic diastolic blood pressure. The prevalence of impaired renal function, left ventricular hypertrophy, and carotid intima\u2010media thickness in patients with\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              were higher than in normotensive patients (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), whereas impaired renal function and left ventricular hypertrophy in these patients were lower than patients in the day\u2013night sustained hypertension group (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05).\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              was correlated with estimated glomerular filtration rate, left ventricular mass index, and carotid intima\u2010media thickness according to multiple linear regression analyses.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The prevalence of\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              in\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              patients was high, and\n              <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n              was correlated with target\u2010organ damage in\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              patients.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002025","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T03:00:12Z","timestamp":1434682812000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["High Prevalence of Isolated Nocturnal Hypertension in Chinese Patients With Chronic Kidney Disease"],"prefix":"10.1161","volume":"4","author":[{"given":"Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yu","family":"Gong","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun\u2010Zi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, 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