{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:49:39Z","timestamp":1791265779958,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,10,27]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Success of cardiac rehabilitation (\n              <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n              ) is generally assessed by the objective improvement in peak volume of inhaled oxygen (\n              <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content>\n              <jats:sub>2<\/jats:sub>\n              ) measured by cardiopulmonary exercise test (\n              <jats:styled-content style=\"fixed-case\">CPX<\/jats:styled-content>\n              ). However, cardiac mechanical efficiency and ventricular\u2010arterial coupling (\n              <jats:styled-content style=\"fixed-case\">VAC<\/jats:styled-content>\n              ) are the other important dimensions of the heart failure pathophysiology, which are not included in\n              <jats:styled-content style=\"fixed-case\">CPX<\/jats:styled-content>\n              \u2010derived data. The effect of cardiac rehabilitation on left ventricular (\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              ) efficiency or\n              <jats:styled-content style=\"fixed-case\">VAC<\/jats:styled-content>\n              in unselected heart failure patients has not been studied thus far.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thirty patients with an ejection fraction of \u226445% were recruited for 20 sessions of exercise\u2010based\n              <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n              . Noninvasive\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              pressure\u2010volume loops were constructed and\n              <jats:styled-content style=\"fixed-case\">VAC<\/jats:styled-content>\n              was calculated with the help of applanation tonometry and echocardiography before and after\n              <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n              .\n              <jats:styled-content style=\"fixed-case\">VAC<\/jats:styled-content>\n              showed an improved mechanical efficiency profile and increased significantly from 0.56\u00b10.18 to 0.67\u00b10.21 (\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              mechanical efficiency improved from 43.9\u00b19.1% to 48.8\u00b19.1% (\n              <jats:italic>P<\/jats:italic>\n              =0.01). The change in peak\n              <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content>\n              <jats:sub>2<\/jats:sub>\n              was not in a significant correlation with the change in\n              <jats:styled-content style=\"fixed-case\">VAC<\/jats:styled-content>\n              (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.18;\n              <jats:italic>P<\/jats:italic>\n              =0.31), mechanical efficiency (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.16,\n              <jats:italic>P<\/jats:italic>\n              =0.39), or the change in ejection fraction (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.07;\n              <jats:italic>P<\/jats:italic>\n              =0.68).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n              is associated with an improvement in\n              <jats:styled-content style=\"fixed-case\">VAC<\/jats:styled-content>\n              and\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              mechanical efficiency in heart failure patients. Further studies are needed to determine the incremental value of\n              <jats:styled-content style=\"fixed-case\">VAC<\/jats:styled-content>\n              and mechanical efficiency over\n              <jats:styled-content style=\"fixed-case\">CPX<\/jats:styled-content>\n              \u2010derived data in predicting clinical outcomes.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002084","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T02:29:11Z","timestamp":1444789751000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Cardiopulmonary Exercise Rehabilitation on Left Ventricular Mechanical Efficiency and Ventricular\u2010Arterial Coupling in Patients With Systolic Heart Failure"],"prefix":"10.1161","volume":"4","author":[{"given":"Emre","family":"Aslanger","sequence":"first","affiliation":[{"name":"Department of Cardiology, Yeditepe University Hospital, Ata\u015fehir Lariboisi\u00e8re Hospital, Department of Cardiology, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Assous","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yeditepe University Hospital, Ata\u015fehir Lariboisi\u00e8re Hospital, Department of Cardiology, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bihry","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yeditepe University Hospital, Ata\u015fehir Lariboisi\u00e8re Hospital, Department of Cardiology, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Beauvais","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, Department of Cardiology, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), UMR\u2010S 942, Universit\u00e9 Paris Diderot, DHU FIRE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Logeart","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, Department of Cardiology, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), UMR\u2010S 942, Universit\u00e9 Paris Diderot, DHU FIRE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Cohen\u2010Solal","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, Department of Cardiology, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), UMR\u2010S 942, Universit\u00e9 Paris Diderot, DHU FIRE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151788.08740.5C"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq056"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.454"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.01.009"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.965186"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(49)90788-7"},{"key":"e_1_3_3_8_2","first-page":"H498","article-title":"Total mechanical energy of a ventricular model and cardiac oxygen consumption","volume":"236","author":"Suga H","year":"1979","unstructured":"Suga H. 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