{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:40:22Z","timestamp":1791556822025,"version":"4.3.4"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,9,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Transcatheter aortic valve replacement (\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              ) is an effective alternative to surgical aortic valve replacement in patients at high surgical risk. However, there is little published literature on the exact causes of death.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The PubMed database was systematically searched for studies reporting causes of death within and after 30\u00a0days following\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              . Twenty\u2010eight studies out of 3934 results retrieved were identified. In the overall analysis, 46.4% and 51.6% of deaths were related to noncardiovascular causes within and after the first 30\u00a0days, respectively. Within 30\u00a0days of\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              , infection\/sepsis (18.5%), heart failure (14.7%), and multiorgan failure (13.2%) were the top 3 causes of death. Beyond 30\u00a0days, infection\/sepsis (14.3%), heart failure (14.1%), and sudden death (10.8%) were the most common causes. All possible subgroup analyses were made. No significant differences were seen for proportions of cardiovascular deaths except the comparison between moderate (mean\n              <jats:styled-content style=\"fixed-case\">STS<\/jats:styled-content>\n              score 4 to 8) and high (mean\n              <jats:styled-content style=\"fixed-case\">STS<\/jats:styled-content>\n              score &gt;8) \u2010risk patients after 30\u00a0days post\u2010\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              (56.0% versus 33.5%,\n              <jats:italic>P<\/jats:italic>\n              =0.005).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiovascular and noncardiovascular causes of death are evenly balanced both in the perioperative period and at long\u2010term follow\u2010up after\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              . Infection\/sepsis and heart failure were the most frequent noncardiovascular and cardiovascular causes of death. This study highlights important areas of clinical focus that could further improve outcomes after\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002096","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T02:54:19Z","timestamp":1442890459000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Causes of Death Following Transcatheter Aortic Valve Replacement: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"4","author":[{"given":"Tian\u2010Yuan","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 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