{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:13:51Z","timestamp":1791911631145,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,10,27]]},"abstract":"\n Background<\/jats:title>\n \n Patients with dilated cardiomyopathy (\n DCM<\/jats:styled-content>\n ) may present with ventricular arrhythmias early in the disease course, unrelated to the severity of left ventricular dysfunction. These patients may be classified as having an arrhythmogenic\n DCM<\/jats:styled-content>\n (\n AR<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n ). We investigated the phenotype and natural history of patients with\n AR<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Two hundred eighty\u2010five patients with a recent diagnosis of\n DCM<\/jats:styled-content>\n (median duration of the disease 1\u00a0month, range 0 to 7\u00a0months) and who had Holter monitoring at baseline were comprehensively evaluated and followed for 107\u00a0months (range 29 to 170\u00a0months).\n AR<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n was defined by the presence of \u22651 of the following: unexplained syncope, rapid nonsustained ventricular tachycardia (\u22655\u00a0beats, \u2265150\u00a0bpm), \u22651000 premature ventricular contractions\/24\u00a0hours, and \u226550 ventricular couplets\/24\u00a0hours, in the absence of overt heart failure. The primary end points were sudden cardiac death (\n SCD<\/jats:styled-content>\n ), sustained ventricular tachycardia (\n SVT<\/jats:styled-content>\n ), or ventricular fibrillation (\n VF<\/jats:styled-content>\n ). The secondary end points were death from congestive heart failure or heart transplantation. Of the 285 patients, 109 (38.2%) met criteria for\n AR<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n phenotype.\n AR<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n subjects had a higher incidence of\n SCD<\/jats:styled-content>\n \/\n SVT<\/jats:styled-content>\n \/\n VF<\/jats:styled-content>\n compared with non\u2013\n AR<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n patients (30.3% vs 17.6%,\n P<\/jats:italic>\n =0.022), with no difference in the secondary end points. A\u00a0family history of\n SCD<\/jats:styled-content>\n \/\n SVT<\/jats:styled-content>\n \/\n VF<\/jats:styled-content>\n and the\n AR<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n phenotype were statistically significant and cumulative predictors of\n SCD<\/jats:styled-content>\n \/\n SVT<\/jats:styled-content>\n \/\n VF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n One\u2010third of\n DCM<\/jats:styled-content>\n patients may have an arrhythmogenic phenotype associated with increased risk of arrhythmias during follow\u2010up. A family history of ventricular arrhythmias in\n DCM<\/jats:styled-content>\n predicts a poor prognosis and increased risk of\n SCD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002149","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T00:37:43Z","timestamp":1445042263000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":121,"title":["Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life\u2010Threatening Arrhythmias"],"prefix":"10.1161","volume":"4","author":[{"given":"Anita","family":"Spezzacatene","sequence":"first","affiliation":[{"name":"Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, CO"},{"name":"Cardiovascular Department \u201cOspedali Riuniti\u201d, Hospital and University of Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardiovascular Department \u201cOspedali Riuniti\u201d, Hospital and University of Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Cardiovascular Department \u201cOspedali Riuniti\u201d, Hospital and University of Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Barbati","sequence":"additional","affiliation":[{"name":"Cardiovascular Department \u201cOspedali Riuniti\u201d, Hospital and University of Trieste, Italy"},{"name":"Cardiovascular Center, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Graw","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Brun","sequence":"additional","affiliation":[{"name":"Cardiovascular Department \u201cOspedali Riuniti\u201d, Hospital and University of Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dobromir","family":"Slavov","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Di Lenarda","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto E.","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Towbin","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Saffitz","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank I.","family":"Marcus","sequence":"additional","affiliation":[{"name":"University of Arizona Medical Center, Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R. 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