{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:31:02Z","timestamp":1791196262185,"version":"4.1.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,12]]},"abstract":"\n Background<\/jats:title>\n \n Ventricular arrhythmia is an important cause of late death in patients with repaired tetralogy of Fallot (\n rTOF<\/jats:styled-content>\n ). By using an\n rTOF<\/jats:styled-content>\n canine model, we investigated the role of repolarization alternans and its electrophysiological mechanisms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Six dogs received right ventricular outflow tract (\n RVOT<\/jats:styled-content>\n ) transannular patch, pulmonary valve destruction, and right bundle branch ablation to simulate\n rTOF<\/jats:styled-content>\n . After 1 year, we performed high\u2010resolution dual\u2010voltage and calcium optical mapping to record action potentials and calcium transients on the excised right ventricular outflow tract wedges. Another 6 dogs without operation served as control. The\n rTOF<\/jats:styled-content>\n group was more susceptible to action potential duration alternans (\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n ) and spatially discordant\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n than control (threshold for\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n : 516\u00b136 vs 343\u00b136\u00a0ms;\n P<\/jats:italic>\n =0.017; threshold for discordant\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n : 387\u00b130 vs 310\u00b114\u00a0ms;\n P<\/jats:italic>\n =0.046). We detected 2 episodes of ventricular tachycardia in the\n rTOF<\/jats:styled-content>\n group, but none in the control. Expressions of Kv4.3 and\n KC<\/jats:styled-content>\n h\n IP<\/jats:styled-content>\n 2 decreased in the\n rTOF<\/jats:styled-content>\n group. Expression of connexin 43 also decreased in the\n rTOF<\/jats:styled-content>\n group with a corresponding decrease of conduction velocity and might contribute to spatially discordant\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n . We also found distinct electrophysiological features of the\n RVOT<\/jats:styled-content>\n , including biphasic relationship between magnitude of\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n and pacing cycle length, uncoupling of\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n , and calcium transients alternans, and shortened\n APD<\/jats:styled-content>\n , but unchanged,\n APD<\/jats:styled-content>\n restitution in\n rTOF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We demonstrated novel electrophysiological properties of the\n RVOT<\/jats:styled-content>\n . In an\n rTOF<\/jats:styled-content>\n model, the\n RVOT<\/jats:styled-content>\n exhibits increased susceptibility to temporal and spatially discordant\n APD<\/jats:styled-content>\n \u2010\n ALT<\/jats:styled-content>\n , which was not totally dependent on calcium transient alternans.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002173","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T02:58:38Z","timestamp":1449889118000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Repolarization Alternans and Ventricular Arrhythmia in a Repaired Tetralogy of Fallot Animal Model"],"prefix":"10.1161","volume":"4","author":[{"given":"Shuenn\u2010Nan","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ti","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicine National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Chien","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih\u2010Sharng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jou\u2010Kou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Hwan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Ping","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn\u2010Lee","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine National Taiwan University Hospital National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.02.063"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.726372"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02714-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.2.401"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.2.231"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.963603"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-012-1156-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000450"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.10.1385"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000240542.03986.e7"},{"issue":"6","key":"e_1_3_2_12_2","first-page":"vi77","article-title":"Mechanisms of arrythmogenic cardiac alternans","volume":"9","author":"Wilson LD","year":"2007","unstructured":"Wilson LD, Rosenbaum DS. 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