{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:39:55Z","timestamp":1790699995503,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,9,16]]},"abstract":"\n Background<\/jats:title>\n \n The prognostic significance of premature atrial complex (\n PAC<\/jats:styled-content>\n ) burden is not fully elucidated. We aimed to investigate the relationship between the burden of\n PAC<\/jats:styled-content>\n s and long\u2010term outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We investigated the clinical characteristics of 5371 consecutive patients without atrial fibrillation (\n AF<\/jats:styled-content>\n ) or a permanent pacemaker (\n PPM<\/jats:styled-content>\n ) at baseline who underwent 24\u2010hour electrocardiography monitoring between January 1, 2002, and December 31, 2004. Clinical event data were retrieved from the Bureau of National Health Insurance of Taiwan. During a mean follow\u2010up duration of 10\u00b11\u00a0years, there were 1209 deaths, 1166 cardiovascular\u2010related hospitalizations, 3104 hospitalizations for any reason, 418 cases of new\u2010onset\n AF<\/jats:styled-content>\n , and 132\n PPM<\/jats:styled-content>\n implantations. The optimal cut\u2010off of\n PAC<\/jats:styled-content>\n burden for predicting mortality was 76\u00a0beats per day, with a sensitivity of 63.1% and a specificity of 63.5%. In multivariate analysis, a\n PAC<\/jats:styled-content>\n burden >76\u00a0beats per day was an independent predictor of mortality (hazard ratio: 1.384, 95%\n CI<\/jats:styled-content>\n : 1.230 to 1.558), cardiovascular hospitalization (hazard ratio: 1.284, 95%\n CI<\/jats:styled-content>\n : 1.137 to 1.451), new\u2010onset\n AF<\/jats:styled-content>\n (hazard ratio: 1.757, 95%\n CI<\/jats:styled-content>\n : 1.427 to 2.163), and\n PPM<\/jats:styled-content>\n implantation (hazard ratio: 2.821, 95%\n CI<\/jats:styled-content>\n : 1.898 to 4.192). Patients with frequent\n PAC<\/jats:styled-content>\n had increased risk of mortality attributable to myocardial infarction, heart failure, and sudden cardiac death. Frequent\n PAC<\/jats:styled-content>\n s increased risk of\n PPM<\/jats:styled-content>\n implantation owing to sick sinus syndrome, high\u2010degree atrioventricular block, and\/or\n AF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The burden of\n PAC<\/jats:styled-content>\n s is independently associated with mortality, cardiovascular hospitalization, new\u2010onset\n AF<\/jats:styled-content>\n , and\n PPM<\/jats:styled-content>\n implantation in the long term.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002192","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T22:10:07Z","timestamp":1440713407000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Prognostic Significance of Premature Atrial Complexes Burden in Prediction of Long\u2010Term Outcome"],"prefix":"10.1161","volume":"4","author":[{"given":"Chin\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenn\u2010Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Wei","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze\u2010Fan","family":"Chao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u2010Po","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Alexandra Hospital, Jurong Health, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u2010Chuan","family":"Tuan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2010Nan","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuen\u2010Wang","family":"Chiou","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, Taiwan"},{"name":"Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Ann","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang\u2010Ming University, Taipei, 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