{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:43:23Z","timestamp":1788270203033,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,10,29]]},"abstract":"\n Background<\/jats:title>\n \n In patients with discordance between low\u2010density lipoprotein (\n LDL<\/jats:styled-content>\n ) cholesterol and\n LDL<\/jats:styled-content>\n particle (\n LDL<\/jats:styled-content>\n \u2010P) concentrations, cardiovascular risk more closely correlates with\n LDL<\/jats:styled-content>\n \u2212P.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We investigated the effect of alirocumab, a fully human monoclonal antibody to proprotein convertase subtilisin\/kexin type 9, on lipoprotein particle concentration and size in hypercholesterolemic patients, using nuclear magnetic resonance spectroscopy. Plasma samples were collected from patients receiving alirocumab 150\u00a0mg every 2\u00a0weeks (n=26) or placebo (n=31) during a phase\n II<\/jats:styled-content>\n , double\u2010blind, placebo\u2010controlled trial in patients (\n LDL<\/jats:styled-content>\n cholesterol \u2265100\u00a0mg\/\n dL<\/jats:styled-content>\n ) on a stable atorvastatin dose. In this post hoc analysis, percentage change in concentrations of\n LDL<\/jats:styled-content>\n \u2212P, very\u2010low\u2010density lipoprotein particles, and high\u2010density lipoprotein particles from baseline to week 12 was determined by nuclear magnetic resonance. Alirocumab significantly reduced mean concentrations of total\n LDL<\/jats:styled-content>\n \u2010P (\u221263.3% versus \u22121.0% with placebo) and large (\u221271.3% versus \u221221.8%) and small (\u221254.0% versus +17.8%)\n LDL<\/jats:styled-content>\n \u2010P subfractions and total very\u2010low\u2010density lipoprotein particle concentrations (\u221236.4% versus +33.4%; all\n P<\/jats:italic>\n <0.01). Total high\u2010density lipoprotein particles increased with alirocumab (+11.2% versus +1.4% with placebo;\n P<\/jats:italic>\n <0.01). There were greater increases in large (44.6%) versus medium (17.7%) or small high\u2010density lipoprotein particles (2.8%) with alirocumab.\n LDL<\/jats:styled-content>\n \u2010P size remained relatively unchanged in both groups; however, very\u2010low\u2010density and high\u2010density lipoprotein particle sizes increased to a significantly greater extent with alirocumab.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Alirocumab significantly reduced\n LDL<\/jats:styled-content>\n \u2010C and\n LDL<\/jats:styled-content>\n \u2010P concentrations in hypercholesterolemic patients receiving stable atorvastatin therapy. These findings may be of particular relevance to patients with discordant\n LDL<\/jats:styled-content>\n \u2010C and\n LDL<\/jats:styled-content>\n \u2010P concentrations.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier: NCT01288443.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002224","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T19:46:10Z","timestamp":1536954370000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Effect of PCSK9 Inhibition by Alirocumab on Lipoprotein Particle Concentrations Determined by Nuclear Magnetic Resonance Spectroscopy"],"prefix":"10.1161","volume":"4","author":[{"given":"Michael J.","family":"Koren","sequence":"first","affiliation":[{"name":"Jacksonville Center For Clinical Research, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Kereiakes","sequence":"additional","affiliation":[{"name":"The Christ Hospital Heart and Vascular Center\/The Lindner Research Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Pourfarzib","sequence":"additional","affiliation":[{"name":"Alexion, Cheshire, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Winegar","sequence":"additional","affiliation":[{"name":"LabCorp, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poulabi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc, Tarrytown, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hamon","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc, Tarrytown, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Hanotin","sequence":"additional","affiliation":[{"name":"Sanofi, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"McKenney","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University and National Clinical Research, Richmond, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2007.10.001"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2011.02.001"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-013-6477-6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_3_4_7_2","first-page":"S46","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"24","author":"Stone NJ","year":"2014","unstructured":"Stone NJ, Robinson J, Lichtenstein AH, Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd\u2010Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW. 2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. 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