{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:22:07Z","timestamp":1788621727598,"version":"build-2803163510"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,1,13]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Thoracic aortic aneurysm is usually a clinically silent disease; timely detection is largely dependent upon identification of clinical markers of thoracic aortic disease (\n                      <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n                      ); (bicuspid aortic valve, intracranial aortic aneurysm, bovine aortic arch, or positive family history). Recently, an association of simple renal cysts (\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      ) with abdominal aortic aneurysm and aortic dissection was established. The aim of our study was to evaluate the prevalence of\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      in patients with\n                      <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n                      in order to assess whether the presence of\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      can be used as a predictor of\n                      <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We evaluated the prevalence of\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      in 842 patients with\n                      <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n                      (64.0% males) treated at our institution from 2004 to 2013 and compared to a control group of patients (n=543; 56.2% males). Patients were divided into 4 groups: ascending aortic aneurysm (456; 54.2%); descending aortic aneurysm (86; 10.2%); type A aortic dissection (118; 14.0%); and type B aortic dissection (182; 21.6%).\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      were identified by abdominal computed tomography or magnetic resonance imaging of these patients. Prevalence of\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      is 37.5%, 57.0%, 44.1%, and 47.3% for patients with ascending aneurysm, descending aneurysm, type A dissection, and type B dissection, respectively. Prevalence of\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      in the control group was 15.3%. Prevalence of\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      was not significantly different between male and female aortic disease patients, despite reported general male predominance (2:1), which was also observed in our control group (1.7:1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This study establishes an increased prevalence of\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      in patients with\n                      <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">SRC<\/jats:styled-content>\n                      can potentially be used as a marker for timely detection of patients at risk of\n                      <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.115.002248","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T22:39:32Z","timestamp":1452292772000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Simple Renal Cysts as Markers of Thoracic Aortic Disease"],"prefix":"10.1161","volume":"5","author":[{"given":"Bulat A.","family":"Ziganshin","sequence":"first","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"},{"name":"Department of Surgical Diseases # 2, Kazan State Medical University, Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Theodoropoulos","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad N.","family":"Salloum","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled J.","family":"Zaza","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryann","family":"Tranquilli","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Mojibian","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"},{"name":"Section of Vascular and Interventional Radiology, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neera K.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Fang","sequence":"additional","affiliation":[{"name":"China Center for Health Development Studies, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"},{"name":"Departments of Economics and Preventive Medicine, Stony Brook University, Stony Brook, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Elefteriades","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale\u2010New Haven Hospital, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"National Center for Injury Prevention and Control . 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