{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:31:04Z","timestamp":1761863464848,"version":"3.41.2"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,8,25]]},"abstract":"\n Background<\/jats:title>\n \n Coronary artery disease and left ventricular hypertrophy are prevalent in the chronic kidney disease (\n CKD<\/jats:styled-content>\n ) and renal transplant (\n RT<\/jats:styled-content>\n ) population. Advances in cardiovascular magnetic resonance (\n CMR<\/jats:styled-content>\n ) with blood oxygen level\u2013dependent (\n BOLD<\/jats:styled-content>\n ) technique provides capability to assess myocardial oxygenation as a measure of ischemia. We hypothesized that the myocardial oxygenation response to stress would be impaired in\n CKD<\/jats:styled-content>\n and\n RT<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Fifty\u2010three subjects (23 subjects with\n CKD<\/jats:styled-content>\n , 10\n RT<\/jats:styled-content>\n recipients, 10 hypertensive (\n HT<\/jats:styled-content>\n ) controls, and 10 normal controls without known coronary artery disease) underwent\n CMR<\/jats:styled-content>\n scanning. All groups had cine and\n BOLD CMR<\/jats:styled-content>\n at 3\u00a0T. The\n RT<\/jats:styled-content>\n and\n HT<\/jats:styled-content>\n groups also had late gadolinium\n CMR<\/jats:styled-content>\n to assess infarction\/replacement fibrosis. The\n CKD<\/jats:styled-content>\n group underwent 2\u2010dimensional echocardiography strain to assess fibrosis. Myocardial oxygenation was measured at rest and under stress with adenosine (140\u00a0\u03bcg\/kg per minute) using\n BOLD<\/jats:styled-content>\n signal intensity. A total of 2898 myocardial segments (1200 segments in\n CKD<\/jats:styled-content>\n patients, 552 segments in\n RT<\/jats:styled-content>\n , 480 segments in\n HT<\/jats:styled-content>\n , and 666 segments in normal controls) were compared using linear mixed modeling. Diabetes mellitus (\n P<\/jats:italic>\n =0.47) and hypertension (\n P<\/jats:italic>\n =0.57) were similar between\n CKD<\/jats:styled-content>\n ,\n RT<\/jats:styled-content>\n , and\n HT<\/jats:styled-content>\n groups. The mean\n BOLD<\/jats:styled-content>\n signal intensity change was significantly lower in the\n CKD<\/jats:styled-content>\n and\n RT<\/jats:styled-content>\n groups compared to\n HT<\/jats:styled-content>\n controls and normal controls (\u22120.89\u00b110.63% in\n CKD<\/jats:styled-content>\n versus 5.66\u00b17.87% in\n RT<\/jats:styled-content>\n versus 15.54\u00b19.58% in\n HT<\/jats:styled-content>\n controls versus 16.19\u00b111.11% in normal controls,\n P<\/jats:italic>\n <0.0001).\n BOLD<\/jats:styled-content>\n signal intensity change was associated with estimated glomerular filtration rate (\u03b2=0.16, 95%\n CI<\/jats:styled-content>\n =0.10 to 0.22,\n P<\/jats:italic>\n <0.0001). Left ventricular mass index and left ventricular septal wall diameter were similar between the\n CKD<\/jats:styled-content>\n predialysis,\n RT<\/jats:styled-content>\n , and\n HT<\/jats:styled-content>\n groups. None of the\n CKD<\/jats:styled-content>\n patients had impaired global longitudinal strain and none of the\n RT<\/jats:styled-content>\n group had late gadolinium hyperenhancement.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Myocardial oxygenation response to stress is impaired in\n CKD<\/jats:styled-content>\n patients and\n RT<\/jats:styled-content>\n recipients without known coronary artery disease, and unlikely to be solely accounted for by the presence of diabetes mellitus, left ventricular hypertrophy, or myocardial scarring. The impaired myocardial oxygenation in\n CKD<\/jats:styled-content>\n patients may be associated with declining renal function. Noncontrast\n BOLD CMR<\/jats:styled-content>\n is a promising tool for detecting myocardial ischemia in the\n CKD<\/jats:styled-content>\n population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002249","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T02:00:11Z","timestamp":1439258411000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Impaired Myocardial Oxygenation Response to Stress in Patients With Chronic Kidney Disease"],"prefix":"10.1161","volume":"4","author":[{"given":"Susie","family":"Parnham","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia"},{"name":"School of Medicine, Flinders University, Bedford Park, South Australia, Australia"},{"name":"South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Gleadle","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia"},{"name":"School of Medicine, Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory, Cardiovascular Outcomes Group, New York University School of Medicine, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchi","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia"},{"name":"South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia"},{"name":"School of Medicine, Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Woodman","sequence":"additional","affiliation":[{"name":"Flinders Centre for Epidemiology and Biostatistics, School of Medicine, Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine G.","family":"De Pasquale","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia"},{"name":"School of Medicine, Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"Selvanayagam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia"},{"name":"School of Medicine, Flinders University, Bedford Park, South Australia, Australia"},{"name":"South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101085"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004030203"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000061602.03327.E2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000235527.81917.fe"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090765"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.11.042"},{"key":"e_1_3_3_8_2","first-page":"S16","article-title":"Epidemiology of cardiovascular disease in chronic renal disease","volume":"9","author":"Foley RN","year":"1998","unstructured":"Foley RN, Parfrey PS, Sarnak MJ. 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