{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:05:23Z","timestamp":1785017123894,"version":"3.55.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,9,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              It is unclear whether antihypertensive treatment can restore cardiovascular disease risk to the risk level of persons with ideal blood pressure (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              ) levels.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Data from the Multi\u2010Ethnic Study of Atherosclerosis (\n              <jats:styled-content style=\"fixed-case\">MESA<\/jats:styled-content>\n              ) and the Coronary Artery Risk Development in Young Adults (\n              <jats:styled-content style=\"fixed-case\">CARDIA<\/jats:styled-content>\n              ) study were analyzed. Outcomes were compared among participants without or with antihypertensive treatment at 3\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              levels: &lt;120\/&lt;80\u00a0mm\u00a0Hg, systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              120 to 139\u00a0mm\u00a0Hg or diastolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              80 to 89\u00a0mm\u00a0Hg (120 to 129\/\u226480\u00a0mm\u00a0Hg for participants with diabetes), and systolic BP \u2265140 or diastolic BP \u226590\u00a0mm\u00a0Hg (systolic BP \u2265130 or diastolic BP \u226580\u00a0mm\u00a0Hg for participants with diabetes). Among\n              <jats:styled-content style=\"fixed-case\">MESA<\/jats:styled-content>\n              participants aged \u226550\u00a0years at baseline, those with\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              &lt;120\/&lt;80\u00a0mm\u00a0Hg on treatment had higher left ventricular mass index, prevalence of estimated glomerular filtration rate &lt;60\u00a0mL\/min per 1.73\u00a0m\n              <jats:sup>2<\/jats:sup>\n              , prevalence of coronary calcium score &gt;100, and twice the incident cardiovascular disease rate over 9.5\u00a0years of follow\u2010up than those with\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              &lt;120\/&lt;80\u00a0mm\u00a0Hg without treatment. In\n              <jats:styled-content style=\"fixed-case\">CARDIA<\/jats:styled-content>\n              at year 25, persons with\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              &lt;120\/&lt;80\u00a0mm\u00a0Hg with treatment had much longer exposure to higher\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              and higher risk of end\u2010organ damage and subclinical atherosclerosis than those with\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              &lt;120\/&lt;80\u00a0mm\u00a0Hg without treatment. An exploratory analysis suggested that when cumulative systolic BP was high (eg, &gt;3000\u00a0mm\u00a0Hg\u2013years in 25\u00a0years), the increase in left ventricular mass index accelerated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The data suggest that based on the current approach, antihypertensive treatment cannot restore cardiovascular disease risk to ideal levels. Emphasis should be placed on primordial prevention of\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              increases to further reduce cardiovascular disease morbidity and mortality.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002275","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T02:54:19Z","timestamp":1442890459000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":114,"title":["Can Antihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?"],"prefix":"10.1161","volume":"4","author":[{"given":"Kiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura 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