{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:42:46Z","timestamp":1769114566113,"version":"3.49.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,10,27]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Although animal studies have documented metformin's cardioprotective effects, the impact in humans remains elusive. The study objective was to explore the association between metformin and myocardial infarct size in patients with diabetes presenting with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Data extraction used the National Cardiovascular Data Cath\n              <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>\n              Registry in all patients with diabetes aged &gt;18 years presenting with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction at 2 academic medical centers from January 2010 to December 2013. The exposure of interest was ongoing metformin use before the event. Propensity score matching was used for the metformin and nonmetformin groups on key prognostic variables. All matched pairs had acceptable D scores of &lt;10%, confirming an efficient matching procedure. The primary outcome was myocardial infarct size, reflected by peak serum creatine kinase\u2013myocardial band, troponin T, and hospital discharge left ventricular ejection fraction. Of all 1726\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction cases reviewed, 493 patients had diabetes (28.5%), with 208 metformin users (42.1%) and 285 nonusers. Matched pairs analysis yielded 137 cases per group. The difference between metformin and nonmetformin groups was \u221218.1\u00a0ng\/mL (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u221255.0 to 18.8;\n              <jats:italic>P<\/jats:italic>\n              =0.56) for total peak serum creatine kinase\u2013myocardial band and \u22121.1\u00a0ng\/mL (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22122.8 to 0.5;\n              <jats:italic>P<\/jats:italic>\n              =0.41) for troponin T. Median discharge left ventricular ejection fraction in both groups was 45, and the difference between metformin and nonmetformin users was 0.7% (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22122.2 to 3.6;\n              <jats:italic>P<\/jats:italic>\n              =0.99).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              No statistically significant association of cardioprotection was found between metformin and myocardial infarct size in patients with diabetes and acute\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002314","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T19:23:51Z","timestamp":1536953031000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Metformin and Myocardial Injury in Patients With Diabetes and ST\u2010Segment Elevation Myocardial Infarction: A Propensity Score Matched Analysis"],"prefix":"10.1161","volume":"4","author":[{"given":"Suresh","family":"Basnet","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Valley Health System, Winchester, VA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Kozikowski","sequence":"additional","affiliation":[{"name":"Department of Medicine, North Shore\u2010LIJ Health System, Great Neck, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amgad N.","family":"Makaryus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Shore\u2010LIJ Health System, Manhasset, NY"},{"name":"Nassau University Medical Center, East Meadow, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Pekmezaris","sequence":"additional","affiliation":[{"name":"Department of Medicine, North Shore\u2010LIJ Health System, Great Neck, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Zeltser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Shore\u2010LIJ Health System, Manhasset, NY"},{"name":"Nassau University Medical Center, East Meadow, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Akerman","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, The Feinstein Institute for Medical Research, North Shore\u2010LIJ Health System, Manhasset, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lesser","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, The Feinstein Institute for Medical Research, North Shore\u2010LIJ Health System, Manhasset, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele","family":"Wolf\u2010Klein","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, North Shore\u2010LIJ Health System, New Hyde Park, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"American Heart Association . 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