{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:31:31Z","timestamp":1787959891835,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,1,13]]},"abstract":"\n Background<\/jats:title>\n \n We aimed to assess trends in hospitalization, outcomes, and resource utilization among patients admitted with adult congenital heart disease (\n ACHD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We used the 2003\u20132012\n US<\/jats:styled-content>\n Nationwide Inpatient Sample for this study. All admissions with an\n ACHD<\/jats:styled-content>\n were identified using standard\n ICD<\/jats:styled-content>\n codes. Resource utilization was assessed using length of stay, invasive procedure utilization, and cost of hospitalization. There was a significant increase in the number of both simple (101%) as well as complex congenital heart disease (53%)\u2013related admissions across 2003\u20132012. In addition, there was a considerable increase in the prevalence of traditional cardiovascular risk factors including older age, along with a higher prevalence of hypertension, diabetes, smoking, obesity, chronic kidney disease, and peripheral arterial disease. Besides miscellaneous causes, congestive heart failure (11.8%), valve disease (15.5%), and cerebrovascular accident (26.1%) were the top causes of admission to the hospital among patients with complex\n ACHD<\/jats:styled-content>\n , simple\n ACHD<\/jats:styled-content>\n without atrial septal defects\/patent foramen ovale and simple atrial septal defects\/patent foramen ovale patients, respectively. In\u2010hospital mortality has been relatively constant among patients with complex\n ACHD<\/jats:styled-content>\n as well as simple\n ACHD<\/jats:styled-content>\n without atrial septal defects\/patent foramen ovale. However, there has been considerable increase in the average length of stay and cost of hospitalization among the\n ACHD<\/jats:styled-content>\n patients during 2003\u20132012.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n There has been a progressive increase in\n ACHD<\/jats:styled-content>\n admissions across 2003\u20132012 in the United States, with increasing healthcare resource utilization among these patients. Moreover, there has been a change in the cardiovascular comorbidities of these patients, adding a layer of complexity in management of\n ACHD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002330","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T17:58:07Z","timestamp":1536947887000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":104,"title":["Nationwide Hospitalization Trends in Adult Congenital Heart Disease Across 2003\u20132012"],"prefix":"10.1161","volume":"5","author":[{"given":"Shikhar","family":"Agarwal","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Sud","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venu","family":"Menon","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01272-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht358"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.037"},{"key":"e_1_3_3_5_2","unstructured":"Healthcare utilization project. Agency for Healthcare Research & Quality. Available at: http:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/nisdde.jsp. Accessed May 5 2015."},{"key":"e_1_3_3_6_2","volume-title":"HCUP Comorbidity Software","author":"Healthcare Cost and Utilization Project (HCUP)","year":"2013","unstructured":"Healthcare Cost and Utilization Project (HCUP) . HCUP Comorbidity Software 1\u201014\u20102013. Rockville, MD: Agency for Healthcare Research and Quality; 2013."},{"key":"e_1_3_3_7_2","unstructured":"Consumer Price Index\u2014Guide to CPI data. United States Department of Labor. Bureau of Labor Statistics. Available at: http:\/\/www.bls.gov\/cpi\/cpifact8.htm. Accessed May 25 2014."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780040112"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.02.013"},{"key":"e_1_3_3_10_2","unstructured":"Adult Congenital Heart Association . Available at: http:\/\/www.achaheart.org\/home\/clinic-directory.aspx. 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Public law 111\u2010148 US Government Printing Office; 2010."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301440"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009639"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211716"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2014.05.016"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.002330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:47:05Z","timestamp":1715597225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.002330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,13]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,13]]}},"alternative-id":["10.1161\/JAHA.115.002330"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.002330","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,13]]},"assertion":[{"value":"2015-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002330"}}