{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:13:00Z","timestamp":1762866780790,"version":"3.41.2"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,12]]},"abstract":"\n Background<\/jats:title>\n \n Atherosclerosis begins in childhood with the occurrence of inflammatory vascular wall alterations that are detectable with B\u2010mode ultrasound. Chemokines appear to be involved in the development of these alterations given that they occur early in the atherosclerotic pathway as mediators of vascular inflammation. However, this has not extensively been investigated. Therefore, we studied in healthy young children whether chemokines monocyte chemotactic protein 1 (\n MCP<\/jats:styled-content>\n \u20101), regulated on activation normal T\u2010cell expressed and secreted (\n RANTES<\/jats:styled-content>\n ), and vascular and intercellular adhesion molecules (\n VCAM<\/jats:styled-content>\n and\n ICAM<\/jats:styled-content>\n ) related to vascular characteristics of the carotid artery.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We obtained demography, anthropometry, and overnight fasting plasma of 139 eight\u2010year\u2010old children of the Wheezing Illnesses Study Leidsche Rijn birth cohort. Carotid intima\u2010media thickness (\n CIMT<\/jats:styled-content>\n ), distensibility, and Young's Elastic Modulus (\n YEM<\/jats:styled-content>\n ) of the common carotid artery were measured sonographically. Chemokine plasma levels were assessed using a multiplex assay. We studied the relation between the chemokines and vascular characteristics using multivariable linear regression analyses with adjustments for sex, systolic blood pressure, homeostasis model assessment of insulin resistance, triglycerides, low\u2010density lipoprotein\u2010 and high\u2010density lipoprotein\u2010cholesterol. Of the studied chemokines,\n RANTES<\/jats:styled-content>\n related to common carotid distensibility and\n YEM<\/jats:styled-content>\n . One standard deviation increase in\n RANTES<\/jats:styled-content>\n level related to a 5.45\u2010\n MPA<\/jats:styled-content>\n \u22121<\/jats:sup>\n (95% confidence interval [\n CI<\/jats:styled-content>\n ], \u22129.43, \u22121.39;\n P<\/jats:italic>\n =0.01) decrease in distensibility and to a 5.55\u2010kPa increase in\n YEM<\/jats:styled-content>\n (95%\n CI<\/jats:styled-content>\n , 0.40, 10.85;\n P<\/jats:italic>\n =0.03).\n RANTES<\/jats:styled-content>\n did not relate to\n CIMT<\/jats:styled-content>\n .\n MCP<\/jats:styled-content>\n \u20101,\n VCAM<\/jats:styled-content>\n , and\n ICAM<\/jats:styled-content>\n did not relate to any of the studied vascular characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n RANTES<\/jats:styled-content>\n appears to be involved in the development of preatherosclerotic inflammatory vascular alterations already in healthy, young children. This may provide further insight into the early\u2010life origins of atherosclerosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002346","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T03:53:57Z","timestamp":1450324437000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Relation Between Circulating Inflammatory Chemokines and Vascular Characteristics in Healthy, Young Children"],"prefix":"10.1161","volume":"4","author":[{"given":"Anouk L. M.","family":"Eikendal","sequence":"first","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke M. V.","family":"Evelein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuno S. P. M.","family":"Uiterwaal","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis K.","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank L. J.","family":"Visseren","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel L.","family":"Bots","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imo E.","family":"Hoefer","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hester M.","family":"den Ruijter","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geertje W.","family":"Dalmeijer","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.9.1291"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7141.1328"},{"key":"e_1_3_2_5_2","first-page":"164","article-title":"Endothelial adhesion molecules in health and disease","volume":"46","author":"Cotran RS","year":"1998","unstructured":"Cotran RS, Mayadas\u2010Norton T. 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