{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:44:58Z","timestamp":1783331098922,"version":"3.54.6"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,10,29]]},"abstract":"\n Background<\/jats:title>\n \n The effect of alcohol consumption on substrate remodeling and ablation outcome of paroxysmal atrial fibrillation (\n PAF<\/jats:styled-content>\n ) remains unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We performed circumferential pulmonary vein isolation (\n CPVI<\/jats:styled-content>\n ) and voltage mapping of left atrium (\n LA<\/jats:styled-content>\n ) during sinus rhythm in 122 consecutive patients with symptomatic\n PAF<\/jats:styled-content>\n (age, 55.4\u00b19.4\u00a0years; 73.8% men). Low\u2010voltage zones (\n LVZ<\/jats:styled-content>\n s) were semiquantitatively estimated and presented as low\u2010voltage index (\n LVI<\/jats:styled-content>\n ). Each patient's daily alcohol consumption history was recorded at baseline and classified into alcohol abstainers, moderate drinkers, and heavy drinkers based on the National Institute on Alcohol Abuse and Alcoholism definition. Follow\u2010up was \u226512\u00a0months for\n AF<\/jats:styled-content>\n recurrence. Alcohol abstainers and moderate and heavy drinkers were 70 (57.4%), 13 (10.6%), and 39 (32.0%), respectively. In total,\n LVZ<\/jats:styled-content>\n s were observed in 44 patients (36.1%). Daily alcohol consumption independently predicted presence of\n LVZ<\/jats:styled-content>\n s (odds ratio [\n OR<\/jats:styled-content>\n ], 1.097; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 1.001\u20131.203;\n P<\/jats:italic>\n =0.047). During mean follow\u2010up of 20.9\u00b15.9\u00a0months, 40 patients (35.1%) experienced\n AF<\/jats:styled-content>\n recurrence. Success rate was 81.3%, 69.2%, and 35.1% in alcohol abstainers, moderate drinkers, and heavy drinkers, respectively (overall log rank,\n P<\/jats:italic>\n <0.001). Multivariate analysis showed that both alcohol consumption and\n LVI<\/jats:styled-content>\n were independent predictors of\n AF<\/jats:styled-content>\n recurrence (hazard ratio [\n HR<\/jats:styled-content>\n ], 1.579; 95%\n CI<\/jats:styled-content>\n , 1.085\u20132.298;\n P<\/jats:italic>\n =0.017;\n HR<\/jats:styled-content>\n , 2.188; 95%\n CI<\/jats:styled-content>\n , 1.582\u20133.026;\n P<\/jats:italic>\n <0.001, respectively). Furthermore, mediation analysis revealed that\n LVZ<\/jats:styled-content>\n s acted as a partial mediator in effect of alcohol consumption on\n AF<\/jats:styled-content>\n ablation outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Daily alcohol consumption was associated with atrial remodelling, and heavy drinkers have substantial risk for\n AF<\/jats:styled-content>\n recurrence after\n CPVI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002349","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T03:28:39Z","timestamp":1447126119000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Impact of Alcohol Consumption on Substrate Remodeling and Ablation Outcome of Paroxysmal Atrial Fibrillation"],"prefix":"10.1161","volume":"4","author":[{"given":"Yu","family":"Qiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbo","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmin","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm027"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.811877"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000689"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.08.641"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.12.004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.755"},{"key":"e_1_3_3_9_2","volume-title":"The Physicians\u2019 Guide to Helping Patients With Alcohol Problems","author":"National Institute of Alcohol Abuse and Alcoholism","year":"1995","unstructured":"National Institute of Alcohol Abuse and Alcoholism . 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