{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:36:04Z","timestamp":1787880964612,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,1,13]]},"abstract":"\n Background<\/jats:title>\n \n Interstage mortality (\n IM<\/jats:styled-content>\n ) remains significant after stage 1 palliation (S1P) for single\u2010ventricle heart disease (\n SVD<\/jats:styled-content>\n ), with many deaths sudden and unexpected. We sought to determine whether digoxin use post\u2010S1P is associated with reduced\n IM<\/jats:styled-content>\n , utilizing the multicenter database of the National Pediatric Cardiology Quality Improvement Collaborative (\n NPCQIC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n From June 2008 to July 2013, 816 infants discharged after S1P from 50 surgical sites completed the interstage to stage\n II<\/jats:styled-content>\n palliation, transplant, or\n IM<\/jats:styled-content>\n . Arrhythmia during S1P hospitalization or discharge on antiarrhythmic medications were exclusions (n=270); 2 patients were lost to follow\u2010up. Two analyses were performed: (1) propensity\u2010score adjusted logistic regression with\n IM<\/jats:styled-content>\n as outcome and (2) retrospective cohort analysis for patients discharged on digoxin versus not, matched for surgical site and other established\n IM<\/jats:styled-content>\n risk factors. Of 544 study patients, 119 (21.9%) were discharged on digoxin. Logistic regression analysis with propensity score, site\u2010size group, and digoxin use as predictor variables showed an increased risk of\n IM<\/jats:styled-content>\n in those not discharged on digoxin (odds ratio, 8.6; lower confidence limit, 1.9; upper confidence limit, 38.3;\n P<\/jats:italic>\n <0.01). The retrospective cohort analysis for 60 patients on digoxin (matched for site of care, type of S1P, post\u2010S1P\n ECMO<\/jats:styled-content>\n use, genetic syndrome, discharge feeding route, ventricular function, tricuspid regurgitation, and aortic arch gradient) showed 0%\n IM<\/jats:styled-content>\n in the digoxin at discharge group and an estimated\n IM<\/jats:styled-content>\n difference between the 2 groups of 9% (\n P<\/jats:italic>\n =0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Among\n SVD<\/jats:styled-content>\n infants in the\n NPCQIC<\/jats:styled-content>\n database discharged post\u2010S1P with no history of arrhythmia, use of digoxin at discharge was associated with reduced\n IM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002376","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T22:39:08Z","timestamp":1452551948000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":71,"title":["Digoxin Use Is Associated With Reduced Interstage Mortality in Patients With No History of Arrhythmia After Stage I Palliation for Single Ventricle Heart Disease"],"prefix":"10.1161","volume":"5","author":[{"given":"David W.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Mangeot","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Independent Consultant, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen C.","family":"King","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Lihn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Neish","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Fleishman","sequence":"additional","affiliation":[{"name":"Arnold Palmer Hospital for Children, Orlando, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Phelps","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hanke","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert H.","family":"Beekman","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole M.","family":"Lannon","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the National Pediatric Cardiology Quality Improvement Collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-0908-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.068684"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14634"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.020"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)01041-2"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.12.091"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.10.011"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0974-7"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1970"},{"key":"e_1_3_4_11_2","first-page":"85","article-title":"A multivariant technique for multiply imputing missing values using a sequence of regression models","volume":"27","author":"Raghunathan TE","year":"2001","unstructured":"Raghunathan TE, Lepkowski JM, Van Hoewyk JV, Solenberger P. A multivariant technique for multiply imputing missing values using a sequence of regression models. Surv Methodol. 2001;27:85\u201395.","journal-title":"Surv Methodol"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.002376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:49:47Z","timestamp":1715582987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.002376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,13]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,13]]}},"alternative-id":["10.1161\/JAHA.115.002376"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.002376","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,13]]},"assertion":[{"value":"2015-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002376"}}