{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:49:42Z","timestamp":1784771382052,"version":"3.55.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,9,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Sirtuin\u20101 (SirT1), a nicotinamide adenine dinucleotide\n              <jats:sup>+<\/jats:sup>\n              \u2013dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. Our goal was to evaluate the role of vascular smooth muscle SirT1 in the physiological response of the aortic wall to angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              , a potent hypertrophic, oxidant, and inflammatory stimulus.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Mice lacking SirT1 in vascular smooth muscle (ie, smooth muscle SirT1 knockout) had drastically high mortality (70%) caused by aortic dissection after angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              infusion (1\u00a0mg\/kg per day) but not after an equipotent dose of norepinephrine, despite comparable blood pressure increases. Smooth muscle SirT1 knockout mice did not show any abnormal aortic morphology or blood pressure compared with wild\u2010type littermates. Nonetheless, in response to angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              , aortas from smooth muscle SirT1 knockout mice had severely disorganized elastic lamellae with frequent elastin breaks, increased oxidant production, and aortic stiffness compared with angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              \u2013treated wild\u2010type mice. Matrix metalloproteinase expression and activity were increased in the aortas of angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              \u2013treated smooth muscle SirT1 knockout mice and were prevented in mice overexpressing SirT1 in vascular smooth muscle or with use of the oxidant scavenger tempol.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Endogenous SirT1 in aortic smooth muscle is required to maintain the structural integrity of the aortic wall in response to oxidant and inflammatory stimuli, at least in part, by suppressing oxidant\u2010induced matrix metalloproteinase activity. SirT1 activators could potentially be a novel therapeutic approach to prevent aortic dissection and rupture in patients at risk, such as those with hypertension or genetic disorders, such as Marfan's syndrome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002384","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T10:14:19Z","timestamp":1536920059000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Vascular Smooth Muscle Sirtuin\u20101 Protects Against Aortic Dissection During Angiotensin II\u2013Induced Hypertension"],"prefix":"10.1161","volume":"4","author":[{"given":"Jessica L.","family":"Fry","sequence":"first","affiliation":[{"name":"Vascular Biology Section, Boston University Medical Campus, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunaga","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Boston University Medical Campus, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Turcotte","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA"},{"name":"Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Z.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA"},{"name":"Health Science Department, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Akiki","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Boston University Medical Campus, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bachschmid","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Boston University Medical Campus, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA"},{"name":"Department of Mechanical Engineering, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen G.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Health Science Department, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Boston University Medical Campus, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Seta","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Boston University Medical Campus, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh0901.089987"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.194753"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340210793611668"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005062"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099196"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.208173"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243592"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.124404"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.237875"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1111-4"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00392.2014"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.042887"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20196"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.05.014"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1364\/AO.30.001369"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.5.003578"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.02.019"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.07.009"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934713100"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.435107"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.2.188"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.025"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.166991"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-012-9349-8"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00249.2012"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118623"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-125468"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14383"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp268"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.07.029"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.484"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.162941"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05354"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.06.011"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.04.018"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.002384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:11:16Z","timestamp":1715595076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.002384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,16]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9,16]]}},"alternative-id":["10.1161\/JAHA.115.002384"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.002384","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,16]]},"assertion":[{"value":"2015-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002384"}}