{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:56:30Z","timestamp":1794009390582,"version":"4.8.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"\n Background<\/jats:title>\n \n Sudden cardiac death (\n SCD<\/jats:styled-content>\n ) is a leading cause of death in the United States and often occurs without previous cardiac symptoms. Lifetime risk for\n SCD<\/jats:styled-content>\n and the influence of established risk factors on lifetime risks for\n SCD<\/jats:styled-content>\n have not been estimated previously.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We followed Framingham Heart Study participants who were free of cardiovascular disease before their earliest examination.\n SCD<\/jats:styled-content>\n was defined as death attributed to coronary heart disease within 1\u00a0hour of symptom onset without another probable cause of death, as adjudicated by a panel of 3 physicians. Lifetime risk for\n SCD<\/jats:styled-content>\n was estimated to 85\u00a0years of age for men and women, with death attributed to other causes as the competing risk, and stratified by risk factor levels. We followed 2294 men and 2785 women for 160\u00a0396\u00a0person\u2010years; 375 experienced\n SCD<\/jats:styled-content>\n . At 45\u00a0years of age, lifetime risks were 10.9% (95%\n CI<\/jats:styled-content>\n , 9.4\u201312.5) for men and 2.8% (95%\n CI<\/jats:styled-content>\n , 2.1\u20133.5) for women. Greater aggregate burden of established risk factors was associated with a higher lifetime risk for\n SCD<\/jats:styled-content>\n . Categorizing men and women solely by blood pressure levels resulted in a clear stratification of lifetime risk curves.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We present the first lifetime risk estimates for\n SCD<\/jats:styled-content>\n . Greater aggregate risk factor burden, or blood pressure level alone, is associated with higher lifetime risks for\n SCD<\/jats:styled-content>\n . This high risk of premature death attributed to\n SCD<\/jats:styled-content>\n (approximately 1 in 9 men and 1 in 30 women) should serve as a motivator of public health efforts in preventing and responding to\n SCD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002398","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T03:44:24Z","timestamp":1467258264000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["Lifetime Risk for Sudden Cardiac Death in the Community"],"prefix":"10.1161","volume":"5","author":[{"given":"Brittany M.","family":"Bogle","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"McCormick School of Engineering, Northwestern University, Evanston, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Goldberger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lloyd\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Medicine, Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.064"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.959734"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000350"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.10.019"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007149"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012848"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.022"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10279-9"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039105.49749.6F"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.548206"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140263.20897.42"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.14312"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb13299.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.4.594"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.16.1966"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.12.011"},{"key":"e_1_3_4_18_2","volume-title":"Some Risk Factors Related to the Annual Incidence of Cardiovascular Disease and Death Using Pooled Repeated Biennial Measurements: Framingham Study, 30\u2010Year Follow\u2010Up: Section\u00a034","author":"Cupples LA","year":"1987","unstructured":"Cupples LA, D'Agostino RB. Some Risk Factors Related to the Annual Incidence of Cardiovascular Disease and Death Using Pooled Repeated Biennial Measurements: Framingham Study, 30\u2010Year Follow\u2010Up: Section\u00a034. Washington, DC: US Government Printing Office; 1987."},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000615\/30)19:11\/12<1495::AID-SIM441>3.0.CO;2-E"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001034"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67394-1"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.666594"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.002398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:13:00Z","timestamp":1715595180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.002398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,6]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7,6]]}},"alternative-id":["10.1161\/JAHA.115.002398"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.002398","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,6]]},"assertion":[{"value":"2015-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002398"}}