{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:27:04Z","timestamp":1782912424831,"version":"3.54.5"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,2,23]]},"abstract":"\n Background<\/jats:title>\n \n The subcutaneous implantable cardioverter defibrillator (S\u2010\n ICD<\/jats:styled-content>\n ) has been developed to avert risks associated with transvenous defibrillator leads. The technology is attractive for younger patients, such as those with hypertrophic cardiomyopathy (HCM). However, there are limited data on S\u2010\n ICD<\/jats:styled-content>\n use in\n HCM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n HCM<\/jats:styled-content>\n patients identified at risk for sudden death were considered for S\u2010\n ICD<\/jats:styled-content>\n implantation. Patients were screened for potential oversensing by surface electrocardiography (ECG). At implant, defibrillation threshold (\n DFT<\/jats:styled-content>\n ) testing was performed at 65, 50, and 35 joules (J). Twenty\u2010seven patients were considered for S\u2010\n ICD<\/jats:styled-content>\n implantation, and after screening, 23 (85%) remained eligible. The presence of a bundle branch block was associated with screening failure, whereas elevated body mass index (BMI) showed a trend toward association. One patient passed screening at rest, but failed with an\n ECG<\/jats:styled-content>\n obtained after exercise. At implant, the S\u2010\n ICD<\/jats:styled-content>\n terminated ventricular fibrillation (\n VF<\/jats:styled-content>\n ) with a 65J shock in all 15 implanted patients and a 50J shock was successful in 12 of 15. A 35J shock terminated\n VF<\/jats:styled-content>\n in 10 of 12 patients.\n DFT<\/jats:styled-content>\n failure at 50\u00a0J was associated with a higher\n BMI<\/jats:styled-content>\n . There were no appropriate shocks after a median follow\u2010up of 17.5 (3\u201335) months, and 1 patient received an inappropriate shock attributable to a temporary reduction in\n QRS<\/jats:styled-content>\n amplitude while bending forward, resulting in oversensing, despite successful screening.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In a high\u2010risk\n HCM<\/jats:styled-content>\n cohort without a pacing indication referred for consideration of an\n ICD<\/jats:styled-content>\n , the majority were eligible for S\u2010\n ICD<\/jats:styled-content>\n . The S\u2010\n ICD<\/jats:styled-content>\n is effective at recognizing and terminating\n VF<\/jats:styled-content>\n at implant with a wide safety margin.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002488","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T13:11:36Z","timestamp":1536930696000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Subcutaneous Implantable Cardioverter Defibrillator in Patients With Hypertrophic Cardiomyopathy: An Initial Experience"],"prefix":"10.1161","volume":"5","author":[{"given":"Jonathan","family":"Weinstock","sequence":"first","affiliation":[{"name":"Cardiac Arrhythmia Center and The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef H.","family":"Bader","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center and The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center and The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan J.","family":"Rowin","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center and The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Link","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center and The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002103420601"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.037"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01683.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003042"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu112"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2010.02843.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-012-0297-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.04.025"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12343"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut370"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.130.suppl_2.12223"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960240313"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.975219"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.053744"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.002488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:24:30Z","timestamp":1715595870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.002488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2,23]]}},"alternative-id":["10.1161\/JAHA.115.002488"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.002488","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]},"assertion":[{"value":"2015-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002488"}}