{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:33:34Z","timestamp":1783971214089,"version":"3.55.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,10,29]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Although cancer and its corresponding therapies are associated with increased ischemic heart disease, the temporal relationship between cancer and the development of coronary artery calcium (\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              ), a marker of subclinical atherosclerosis, is unknown.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among 3122 men and women free of cardiovascular disease and cancer in the Multi\u2010Ethnic Study of Atherosclerosis trial,\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              scoring was performed at baseline (2000\u20132002) and at follow\u2010up (2010\u20132012). Over this 10\u2010year period, 85 men (age 63.6\u00b18.3\u00a0years) and 50 women (age 62.1\u00b19.8\u00a0years) were diagnosed with cancer (predominantly breast, lung, or uterine [52%] in women and prostate or colorectal [78%] in men). The other 2987 subjects (age 59.6\u00b19.2\u00a0years for men, 59.7\u00b19.4\u00a0years for women) remained cancer free. The incidence of new\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              (baseline Agatston score of zero converting to detectable\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              ) was modeled with relative risk regression and compared for cancer versus no cancer. Increase in pre\u2010existing\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              was compared in these groups using linear regression of log transformed\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              . The incidence of\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              was independently associated with cancer history (relative risk 1.32 [\n              <jats:italic>P<\/jats:italic>\n              =0.04] and 1.29 [\n              <jats:italic>P<\/jats:italic>\n              =0.01] for women and men, respectively). In participants with\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              at baseline, a clear difference of\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              progression was not observed between cancer and noncancer participants (\n              <jats:italic>P<\/jats:italic>\n              =0.6 for women,\n              <jats:italic>P<\/jats:italic>\n              =0.2 for men).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A diagnosis of cancer is associated with the development of\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              even after accounting for atherosclerotic risk factors. However, in individuals with pre\u2010existing\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              , it is not clear whether the presence of cancer accelerates\n              <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n              over time.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002533","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T03:28:39Z","timestamp":1447126119000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["Cancer and Its Association With the Development of Coronary Artery Calcification: An Assessment From the Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1161","volume":"4","author":[{"given":"Matthew C.","family":"Whitlock","sequence":"first","affiliation":[{"name":"Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Yeboah","sequence":"additional","affiliation":[{"name":"Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi D.","family":"Klepin","sequence":"additional","affiliation":[{"name":"Section on Hematology\u2010Oncology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Gregory","family":"Hundley","sequence":"additional","affiliation":[{"name":"Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC"},{"name":"Department of Radiological Sciences, Wake Forest School of Medicine, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk064"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.7193"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034405"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA..107.181425"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3112"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.005"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.01.006"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws169"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2007.S5"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2341040439"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.580696"},{"key":"e_1_3_4_15_2","unstructured":"Kronmal R. 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