{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:06:38Z","timestamp":1789679198718,"version":"4.0.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,4,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The polyphenol resveratrol (Rev) has been reported to exhibit cardioprotective effects, such as inhibition of\n              <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n              (transverse aortic constriction) or isoprenaline (ISO)\u2010induced hypertrophy. Micro\n              <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n              \u2010155 (miR\u2010155) was found to be decreased in hypertrophic myocardium, which could be further reduced by pretreatment of Rev. The study was designed to investigate the molecular effects of miR\u2010155 on cardiac hypertrophy, focusing on the role of breast cancer type 1 susceptibility protein (\n              <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>\n              1).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We demonstrated that Rev alleviated severity of hypertrophic myocardium in a mice model of cardiac hypertrophy by\n              <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n              treatment. Down\u2010regulation of miR\u2010155 was observed in pressure overload\u2013 or\n              <jats:styled-content style=\"fixed-case\">ISO<\/jats:styled-content>\n              \u2010induced hypertrophic cardiomyoctyes. Interestingly, administration of Rev substantially attenuated miR\u2010155 level in cardiomyocytes. In agreement with its miR\u2010155 reducing effect, Rev relieved cardiac hypertrophy and restored cardiac function by activation of\n              <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>\n              1 in cardiomyoctyes. Our results further revealed that forkhead box O3a (FoxO3a) was a miR\u2010155 target in the heart. And miR\u2010155 directly repressed FoxO3a, whose expression was mitigated in miR\u2010155 agomir and mimic treatment in\u00a0vivo and in\u00a0vitro.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conclude that\n              <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>\n              1 inactivation can increase expression of miR\u2010155, contributing to cardiac hypertrophy. And Rev produces their beneficial effects partially by down\u2010regulating miR\u2010155 expression, which might be a novel strategy for treatment of cardiac hypertrophy.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002648","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T03:23:27Z","timestamp":1461381807000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Resveratrol Ameliorates Cardiac Hypertrophy by Down\u2010regulation of miR\u2010155 Through Activation of Breast Cancer Type 1 Susceptibility Protein"],"prefix":"10.1161","volume":"5","author":[{"given":"Yuhua","family":"Fan","sequence":"first","affiliation":[{"name":"College of Pharmacy, Harbin Medical University\u2010Daqing, Daqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Third Hospital of Harbin Medical University, Harbin, Heilongjiang, China"},{"name":"Key Laboratory of Cardiovascular Medicine Research (Harbin Medical University), Ministry of Education, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Harbin Medical University\u2010Daqing, Daqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"Radiology Department and Molecular Imaging Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wan","sequence":"additional","affiliation":[{"name":"Radiology Department and Molecular Imaging Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, 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Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fourth Hospital of Harbin Medical University, Nangang District Harbin, Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Medicine Research (Harbin Medical University), Ministry of Education, Harbin, China"},{"name":"College of Pharmacy, Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fourth Hospital of Harbin Medical University, Nangang District Harbin, Heilongjiang, 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